Oxlumo (lumasiran) Disease Interactions
There are 2 disease interactions with Oxlumo (lumasiran):
Lumasiran (Includes Oxlumo) ↔ liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal with any AST). Caution is recommended if used in these patients.
Lumasiran (Includes Oxlumo) ↔ renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Lumasiran has not been studied in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2 or patients on dialysis. Caution is recommended if used in these patients.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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