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Oxlumo Disease Interactions

There are 2 disease interactions with Oxlumo (lumasiran).

Moderate

Lumasiran (applies to Oxlumo) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal with any AST). Caution is recommended if used in these patients.

References

  1. (2020) "Product Information. Oxlumo (lumasiran)." Alnylam Pharmaceuticals
Moderate

Lumasiran (applies to Oxlumo) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Lumasiran has not been studied in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2 or patients on dialysis. Caution is recommended if used in these patients.

References

  1. (2020) "Product Information. Oxlumo (lumasiran)." Alnylam Pharmaceuticals

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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