Lonafarnib Disease Interactions
There are 2 disease interactions with lonafarnib:
Lonafarnib (Includes lonafarnib) ↔ hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Hepatic transaminase elevations (i.e., aspartate aminotransferase AST] and alanine aminotransferase ([ALT]) have been reported during lonafarnib therapy. Often these elevations improve with continued therapy, but it is not possible to exclude this drug as a cause of the abnormalities. Liver enzymes should be monitored periodically during therapy.
Lonafarnib (Includes lonafarnib) ↔ nephrotoxicity
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Lonafarnib has not been studied in patients with renal impairment, however, this drug caused nephrotoxicity in rats at plasma drug exposures approximately equal to that achieved with the human dose. Renal function should be monitored at regular intervals during therapy.
Lonafarnib drug interactions
There are 415 drug interactions with lonafarnib
Lonafarnib alcohol/food interactions
There is 1 alcohol/food interaction with lonafarnib
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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