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Lonafarnib Disease Interactions

There are 2 disease interactions with lonafarnib.

Moderate

Lonafarnib (applies to lonafarnib) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Hepatic transaminase elevations (i.e., aspartate aminotransferase AST] and alanine aminotransferase ([ALT]) have been reported during lonafarnib therapy. Often these elevations improve with continued therapy, but it is not possible to exclude this drug as a cause of the abnormalities. Liver enzymes should be monitored periodically during therapy.

Moderate

Lonafarnib (applies to lonafarnib) nephrotoxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Lonafarnib has not been studied in patients with renal impairment, however, this drug caused nephrotoxicity in rats at plasma drug exposures approximately equal to that achieved with the human dose. Renal function should be monitored at regular intervals during therapy.

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Lonafarnib drug interactions

There are 522 drug interactions with lonafarnib.

Lonafarnib alcohol/food interactions

There is 1 alcohol/food interaction with lonafarnib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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