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Lindane topical Disease Interactions

There is 1 disease interaction with lindane topical:


Lindane Topical (Includes Lindane topical) ↔ Seizure Disorders

Severe Potential Hazard, High plausibility

Applies to: Seizures, Prematurity/Underweight in Infancy

The use of lindane is contraindicated in patients with seizure disorders. Topically applied lindane is systemically absorbed and has induced CNS toxicity such as dizziness, headache, disorientation, and seizures. Although seizures have generally occurred due to product misuse or oral ingestion, they have also been reported occasionally when used as directed. Lindane use is also contraindicated in premature neonates due to the likelihood of increased skin permeability.


  1. Tenenbein M "Seizures after lindane therapy." J Am Geriatr Soc 39 (1991): 394-5
  2. "Product Information. Kwell (lindane)." Reed and Carnrick, Jersey City, NJ.
  3. Pramanik AK, Hansen RC "Transcutaneous gamma benzene hexachloride absorption and toxicity in infants and children." Arch Dermatol 115 (1979): 1224-5
  4. Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9
View all 4 references

lindane topical drug Interactions

There are 357 drug interactions with lindane topical

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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