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Actimmune (interferon gamma-1b) Disease Interactions

There are 3 disease interactions with Actimmune (interferon gamma-1b):

Major

Interferons (Includes Actimmune) ↔ Cardiac Disease

Severe Potential Hazard, High plausibility

Applies to: Congestive Heart Failure, Ischemic Heart Disease, Arrhythmias

Hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure have been reported during interferon therapy. Therapy with interferons should be administered with caution in patients with compromised cardiac function.

References

  1. "Product Information. Intron A (interferon alfa-2b)." Schering Laboratories, Kenilworth, NJ.
  2. "Product Information. Avonex (interferon beta-1a)." Biogen, Cambridge, MA.
  3. "Product Information. Betaseron (interferon beta-1b)." Berlex, Richmond, CA.
View all 4 references
Major

Interferons (Includes Actimmune) ↔ Cns Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Parkinsonism, Seizures, Psychosis

Reversible CNS effects such as seizures, mental status changes, manic behavior or psychotic reactions, gait disturbances, and dizziness have occurred in patients receiving interferons. Therapy with interferons should be administered cautiously in patients with or predisposed to seizures, psychiatric disorders, or conditions affecting posture or gait.

References

  1. "Product Information. Intron A (interferon alfa-2b)." Schering Laboratories, Kenilworth, NJ.
  2. "Product Information. Infergen (interferon alfacon-1)." Amgen, Thousand Oaks, CA.
  3. "Product Information. Betaseron (interferon beta-1b)." Berlex, Richmond, CA.
View all 4 references
Moderate

Interferons (Includes Actimmune) ↔ Myelosuppression

Moderate Potential Hazard, Moderate plausibility

Applies to: Bone Marrow Depression/Low Blood Counts

Interferons (alfa and gamma) induce a dose-dependent, generally mild, myelosuppression. Leukopenia is the primary manifestation. Thrombocytopenia and anemia occur less frequently. Therapy with interferons (alfa and gamma) should be administered cautiously to patients with bone marrow suppression. Clinical monitoring of hematopoietic function is recommended.

References

  1. "Product Information. Infergen (interferon alfacon-1)." Amgen, Thousand Oaks, CA.
  2. "Product Information. Intron A (interferon alfa-2b)." Schering Laboratories, Kenilworth, NJ.

Actimmune (interferon gamma-1b) drug Interactions

There are 152 drug interactions with Actimmune (interferon gamma-1b)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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