Givlaari Disease Interactions
There is 1 disease interaction with Givlaari (givosiran).
Givosiran (applies to Givlaari) hepatic/renal
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease
The effect of end-stage renal disease (eGFR <15 mL/min/1.73m2), and moderate to severe hepatic impairment on givosiran pharmacokinetics is unknown. Additionally, hepatic and renal toxicity was observed in up to 15% of patients treated with givosiran in clinical trials. Caution and regular monitoring is advised when using givosiran in patients with hepatic or renal impairment.
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Givlaari drug interactions
There are 239 drug interactions with Givlaari (givosiran).
Givlaari alcohol/food interactions
There is 1 alcohol/food interaction with Givlaari (givosiran).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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