Persantine IV Disease Interactions
There are 4 disease interactions with Persantine IV (dipyridamole).
Dipyridamole (applies to Persantine IV) bronchospasm
Major Potential Hazard, Low plausibility. Applicable conditions: Asthma, Chronic Obstructive Pulmonary Disease
Dipyridamole is a phosphodiesterase inhibitor and can exacerbate bronchospasm, particularly in patients with reactive airway disease and/or chronic obstructive pulmonary disease (COPD). Therapy with dipyridamole is contraindicated in patients with active wheezing and should be administered cautiously in patients with asthma or COPD.
Dipyridamole (applies to Persantine IV) conduction abnormalities
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias
Serious adverse reactions associated with the administration of intravenous dipyridamole have included cardiac death, fatal and non- fatal myocardial infarction, ventricular fibrillation, symptomatic ventricular tachycardia, stroke, transient cerebral ischemia, seizures, anaphylactoid reaction and bronchospasm. There have been reported cases of asystole, sinus node arrest, sinus node depression and conduction block. Patients with abnormalities of cardiac impulse formation/conduction or severe coronary artery disease may be at increased risk for these events. Caution is recommended.
Dipyridamole (applies to Persantine IV) hypotension
Moderate Potential Hazard, High plausibility.
Dipyridamole can cause peripheral vasodilation. Therapy with dipyridamole should be administered cautiously in patients with hypotension.
Dipyridamole (applies to Persantine IV) myasthenia gravis
Moderate Potential Hazard, Low plausibility.
Myasthenia gravis patients receiving therapy with cholinesterase inhibitors may experience worsening of their disease in the presence of dipyridamole. Caution should be exercised with these patients.
Persantine IV drug interactions
There are 159 drug interactions with Persantine IV (dipyridamole).
Persantine IV alcohol/food interactions
There are 2 alcohol/food interactions with Persantine IV (dipyridamole).
More about Persantine IV (dipyridamole)
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- During pregnancy
- Drug class: cardiac stressing agents
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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