DHT (dihydrotachysterol) Disease Interactions
There are 4 disease interactions with DHT (dihydrotachysterol):
Vitamin D Analogs (Includes DHT) ↔ Arrhythmia
Severe Potential Hazard, High plausibility
Applies to: Arrhythmias
Vitamin D analogs function to increase serum calcium concentrations and can exacerbate arrhythmias, particularly in patients receiving cardiac glycosides. Therapy with vitamin D analogs should be administered cautiously in patients with or predisposed to cardiac arrhythmias. Clinical monitoring of serum electrolyte concentrations and cardiac function is recommended.
References
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- "Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
- "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.
Vitamin D Analogs (Includes DHT) ↔ Electrolyte Imbalance
Severe Potential Hazard, High plausibility
Applies to: Phosphate Imbalance
Vitamin D analogs administered in the presence of hyperphosphatemia can result in precipitation of calcium-phosphate deposits within the vascular or renal systems or other soft tissue calcifications. A solubility product (Serum Calcium X Phosphate) should not exceed 70. Serum electrolyte concentrations should be corrected prior to vitamin D analog therapy and monitored during therapy.
References
- "Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
- "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- "Product Information. Zemplar (paricalcitol)." Abbott Pharmaceutical, Abbott Park, IL.
Vitamin D Analogs (Includes DHT) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Ergocalciferol, cholecalciferol, and calcifediol undergo renal biotransformation during metabolic activation. Renal impairment can alter metabolic and therapeutic activity of certain vitamin D analogs. Alternative vitamin D analogs such as dihydrotachysterol (hepatic activation) and calcitriol (active form) may be considered in patients with compromised renal function.
References
- "Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
- "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
Vitamin D Analogs (Includes DHT) ↔ Hepatobiliary Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease, Biliary Obstruction
Vitamin D analogs are fat soluble and oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin D analogs. Metabolites of vitamin D analogs are primarily excreted in bile and feces. Ergocalciferol, cholecalciferol, and dihydrotachysterol undergo hepatic hydroxylation during metabolic activation. Hepatic impairment can alter the metabolic and therapeutic activity of certain vitamin D analogs. Alternative vitamin D analogs such as calcifediol (requires renal activation) and calcitriol (active form) may be considered in patients with compromised hepatic function.
References
- "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- "Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
DHT (dihydrotachysterol) drug Interactions
There are 152 drug interactions with DHT (dihydrotachysterol)
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No information available. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.