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DigiFab (digoxin immune fab) Disease Interactions

There are 2 disease interactions with DigiFab (digoxin immune fab):

Moderate

Digoxin immune Fab (applies to DigiFab) potassium imbalance

Moderate Potential Hazard, High plausibility. Applicable conditions: Hyperkalemia, Hypokalemia

Severe digitalis intoxication can result in life-threatening elevations of serum potassium as potassium is shifted from inside the cell to the serum. Elevated serum potassium leads to increased renal elimination of potassium and can result in a total body deficit of potassium. Hypokalemia may develop rapidly following digoxin immune Fab as potassium reenters the cells. Serum potassium concentrations should be monitored prior to, during and following digoxin immune Fab therapy and cautiously replaced as necessary.

References

  1. "Product Information. Digibind (digoxin immune FAB)." Glaxo Wellcome, Research Triangle Park, NC.
  2. Fenton F, Smally AJ, Laut J "Hyperkalemia and digoxin toxicity in a patient with kidney failure." Ann Emerg Med 28 (1996): 440-1
Moderate

Digoxin immune Fab (applies to DigiFab) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Digoxin immune Fab is eliminated by the kidney complexed to digoxin or digitoxin. The elimination half-life of digoxin immune Fab has not been fully defined, however it is expected to be prolonged in patients with severe renal impairment. It is uncertain if failure to eliminate the complex can lead to reintoxication following the release of complexed digoxin/digitoxin. Therapy with digoxin immune Fab should be administered cautiously in patients with severe renal dysfunction. Clinical monitoring of renal function and symptoms of toxicity should be monitored for an extended time. Digoxin immune Fab interferes with digitalis immunoassay measurements.

References

  1. "Product Information. Digibind (digoxin immune FAB)." Glaxo Wellcome, Research Triangle Park, NC.
  2. Fenton F, Smally AJ, Laut J "Hyperkalemia and digoxin toxicity in a patient with kidney failure." Ann Emerg Med 28 (1996): 440-1

DigiFab (digoxin immune fab) drug interactions

There are 16 drug interactions with DigiFab (digoxin immune fab)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.