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Ontak (denileukin diftitox) Disease Interactions

There are 2 disease interactions with Ontak (denileukin diftitox):


Denileukin Diftitox (Includes Ontak) ↔ Edema

Moderate Potential Hazard, Moderate plausibility

Applies to: Fluid Retention

Denileukin diftitox can cause capillary leak syndrome, which could result in edema. Some patients required hospitalization and others intervention to prevent hospitalization. Administration of IV fluids may be necessary to maintain organ perfusion and blood pressure. It is recommended to regularly assess patients for weight gain, new onset or worsening of edema. Denileukin diftitox should be administered cautiously in patients with fixed fluid requirements and/or those adversely affected by fluid overload.


Denileukin Diftitox (Includes Ontak) ↔ Visual Disturbances

Moderate Potential Hazard, Moderate plausibility

Applies to: Visual Defect/Disturbance

Cases of loss of visual acuity, usually with loss of color vision, with or without retinal pigment mottling have been reported with the use of denileukin diftitox. It is recommended to perform an ophthalmological evaluation consisting of best corrected visual acuity, and other evaluations as appropriate for new onset of severe visual loss. Care should be exercised when prescribing denileukin diftitox patients with visual disturbances.

Ontak (denileukin diftitox) drug Interactions

There are 118 drug interactions with Ontak (denileukin diftitox)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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