Amrix Disease Interactions
There are 2 disease interactions with Amrix (cyclobenzaprine).
Cyclobenzaprine (applies to Amrix) cardiovascular disease
Major Potential Hazard, Moderate plausibility. Applicable conditions: Hyperthyroidism, Cerebrovascular Insufficiency, History - Cerebrovascular Disease, History - Myocardial Infarction, Hypotension, Dehydration, Congestive Heart Failure
The manufacturers consider the use of cyclobenzaprine to be contraindicated in the acute recovery phase following myocardial infarction and in patients with hyperthyroidism, congestive heart failure, arrhythmias, heart block, and/or conduction disturbances. Cyclobenzaprine is structurally related to the tricyclic antidepressants, which have been reported to cause tachycardia, arrhythmias, heart block, hypertension, hypotension (particularly orthostatic hypotension), thrombosis, thrombophlebitis, myocardial infarction, strokes, congestive heart failure, and ECG abnormalities such as PR and QT interval prolongation. Therapy with cyclobenzaprine should be administered cautiously in patients with a history of cardiovascular or cerebrovascular disease or a predisposition to hypotension, particularly if the intended dosage exceeds those normally used for musculoskeletal conditions. Tachycardia, arrhythmia, palpitation, and hypotension have been reported with the use of cyclobenzaprine in less than 1% of patients.
References
- O'Riordan W, Gillette P, Calderon J, Stennes RL (1986) "Overdose of cyclobenzaprine, the tricyclic muscle relaxant." Ann Emerg Med, 15, p. 592-3
- Linden CH, Mitchiner JC, Lindzon RD, Rumack BH (1983) "Cyclobenzaprine overdosage." J Toxicol Clin Toxicol, 20, p. 281-8
- (2001) "Product Information. Flexeril (cyclobenzaprine)." Merck & Co., Inc
Cyclobenzaprine (applies to Amrix) anticholinergic effects
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction, Glaucoma/Intraocular Hypertension, Urinary Retention
Cyclobenzaprine has anticholinergic activity, to which elderly patients are particularly sensitive. Therapy with cyclobenzaprine should be administered cautiously in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders. Glaucoma should be treated and under control prior to initiation of cyclobenzaprine therapy, and intraocular pressure monitored during therapy.
References
- Heckerling PS, Bartow TJ (1984) "Paradoxical diaphoresis in cyclobenzaprine poisoning." Ann Intern Med, 101, p. 881
- Linden CH, Mitchiner JC, Lindzon RD, Rumack BH (1983) "Cyclobenzaprine overdosage." J Toxicol Clin Toxicol, 20, p. 281-8
- (2001) "Product Information. Flexeril (cyclobenzaprine)." Merck & Co., Inc
Amrix drug interactions
There are 440 drug interactions with Amrix (cyclobenzaprine).
Amrix alcohol/food interactions
There is 1 alcohol/food interaction with Amrix (cyclobenzaprine).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.