Chloroprocaine Disease Interactions
There are 7 disease interactions with chloroprocaine:
- CV disease
- Hypertensive vascular disease
- Liver impairment
- Renal impairment
Chloroprocaine (applies to chloroprocaine) neuro/spinal
Major Potential Hazard, Moderate plausibility. Applicable conditions: Neurologic Disorder, Scoliosis, Hypertension, Sepsis
Lumbar and caudal epidural anesthesia should be used with extreme caution in persons with neurological disease, spinal deformities, septicemia, and severe hypertension.
Chloroprocaine (applies to chloroprocaine) CV disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease
Local anesthetics such as chloroprocaine should be used with caution in patients with impaired cardiovascular function since they may be less able to compensate for functional changes associated with the prolongation of A-V conduction produced by these drugs.
Chloroprocaine (applies to chloroprocaine) hypertensive vascular disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Hypertension, Peripheral Arterial Disease
Local anesthetic injections containing a vasoconstrictor should be used cautiously and in carefully circumscribed quantities in areas of the body supplied by end arteries or having otherwise compromised blood supply. Patients with peripheral vascular disease and those with hypertensive vascular disease may exhibit exaggerated vasoconstrictor response. Ischemic injury or necrosis may result. Caution is advised.
Chloroprocaine (applies to chloroprocaine) hypotension
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Block
Local anesthetics such as chloroprocaine, should be used with caution in patients with hypotension or heart block.
Chloroprocaine (applies to chloroprocaine) liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Since ester-type local anesthetics like chloroprocaine are hydrolyzed by plasma cholinesterase produced by the liver, chloroprocaine should be used cautiously in patients with hepatic disease.
Chloroprocaine (applies to chloroprocaine) methemoglobinemia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency, Heart Disease
Cases of methemoglobinemia have been reported in association with local anesthetic use such as chloroprocaine. Although all patients are at risk for methemoglobinemia, patients with glucose- 6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age, and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition. If local anesthetics must be used in these patients, close monitoring for symptoms and signs of methemoglobinemia is recommended.
Chloroprocaine (applies to chloroprocaine) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Chloroprocaine and its metabolites are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. The elderly and patients with decreased renal function, might need cautious dose selection and renal function monitoring.
Chloroprocaine drug interactions
There are 34 drug interactions with chloroprocaine
Chloroprocaine alcohol/food interactions
There are 2 alcohol/food interactions with chloroprocaine
More about chloroprocaine
- Side Effects
- Drug Interactions
- Pricing & Coupons
- Drug class: local injectable anesthetics
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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