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Cevimeline Disease Interactions

There are 5 disease interactions with cevimeline:

Major

Cevimeline (Includes Cevimeline) ↔ Cardiovascular Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Cardiovascular Disease, Angina Pectoris, Myocardial Infarction

Cevimeline may alter cardiac conduction and/or heart rate. Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by cevimeline. Cevimeline should be used with caution and under close medical supervision in patients with a history of cardiovascular disease.

Major

Cevimeline (Includes Cevimeline) ↔ Glaucoma

Severe Potential Hazard, Moderate plausibility

Applies to: Uveitis, Glaucoma (Narrow Angle)

Cevimeline is contraindicated when miosis is undesirable, such in patients with narrow-angle (angle-closure) glaucoma or in acute iritis.

Major

Cevimeline (Includes Cevimeline) ↔ Pulmonary Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Asthma, Chronic Obstructive Pulmonary Disease

The use of cevimeline is contraindicated in patients with uncontrolled asthma. Cevimeline can potentially increase airway resistance, bronchial smooth muscle tone, and bronchial secretions. This agent should be administered with caution and with close medical supervision in patients with controlled asthma, chronic bronchitis, or chronic obstructive pulmonary disease.

Moderate

Cevimeline (Includes Cevimeline) ↔ Cholelithiasis

Moderate Potential Hazard, Moderate plausibility

Applies to: Cholelithiasis

Cevimeline should be administered with caution in patients with a history of cholelithiasis. Contractions of the gallbladder or biliary smooth muscle may precipitate complications such as cholecystitis, cholangitis and biliary obstruction.

Moderate

Cevimeline (Includes Cevimeline) ↔ Nephrolithiasis

Moderate Potential Hazard, Moderate plausibility

Applies to: Nephrolithiasis

Cevimeline should be administered with caution to patients with a history of nephrolithiasis. An increase in the ureteral smooth muscle tone may precipitate renal colic or ureteral reflux in patients with nephrolithiasis.

cevimeline drug Interactions

There are 312 drug interactions with cevimeline

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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