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Evoxac (cevimeline) Disease Interactions

There are 5 disease interactions with Evoxac (cevimeline):

Major

Cevimeline (applies to Evoxac) cardiovascular disease

Major Potential Hazard, Moderate plausibility. Applicable conditions: Angina Pectoris, Myocardial Infarction

Cevimeline may alter cardiac conduction and/or heart rate. Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by cevimeline. Cevimeline should be used with caution and under close medical supervision in patients with a history of cardiovascular disease.

Major

Cevimeline (applies to Evoxac) glaucoma

Major Potential Hazard, Moderate plausibility. Applicable conditions: Uveitis, Glaucoma (Narrow Angle)

Cevimeline is contraindicated when miosis is undesirable, such in patients with narrow-angle (angle-closure) glaucoma or in acute iritis.

Major

Cevimeline (applies to Evoxac) pulmonary disease

Major Potential Hazard, Moderate plausibility. Applicable conditions: Asthma, Chronic Obstructive Pulmonary Disease

The use of cevimeline is contraindicated in patients with uncontrolled asthma. Cevimeline can potentially increase airway resistance, bronchial smooth muscle tone, and bronchial secretions. This agent should be administered with caution and with close medical supervision in patients with controlled asthma, chronic bronchitis, or chronic obstructive pulmonary disease.

Moderate

Cevimeline (applies to Evoxac) cholelithiasis

Moderate Potential Hazard, Moderate plausibility.

Cevimeline should be administered with caution in patients with a history of cholelithiasis. Contractions of the gallbladder or biliary smooth muscle may precipitate complications such as cholecystitis, cholangitis and biliary obstruction.

Moderate

Cevimeline (applies to Evoxac) nephrolithiasis

Moderate Potential Hazard, Moderate plausibility.

Cevimeline should be administered with caution to patients with a history of nephrolithiasis. An increase in the ureteral smooth muscle tone may precipitate renal colic or ureteral reflux in patients with nephrolithiasis.

Evoxac (cevimeline) drug interactions

There are 228 drug interactions with Evoxac (cevimeline)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.