Caplacizumab Disease Interactions
There are 2 disease interactions with caplacizumab.
Caplacizumab (applies to caplacizumab) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect
Caplacizumab increases the risk of bleeding. This risk is increased in patients with underlying coagulopathies (e.g., hemophilia, other coagulation factor deficiencies). It is also increased with concomitant use of drugs affecting hemostasis and coagulation. Treatment with caplacizumab should be interrupted if clinically significant bleeding occurs. Caution and close monitoring is advised.
Caplacizumab (applies to caplacizumab) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
No formal studies with caplacizumab have been conducted in patients with severe acute or chronic hepatic impairment and no data regarding the use of the drug in these populations are available. Due to a potential increased risk of bleeding, the use of caplacizumab in patients with severe hepatic impairment requires close monitoring.
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Caplacizumab drug interactions
There are 159 drug interactions with caplacizumab.
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- Drug class: platelet aggregation inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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