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TheraCys (bcg) Disease Interactions

There are 3 disease interactions with TheraCys (bcg):

Major

BCG vaccine (applies to TheraCys) immunodeficiency

Major Potential Hazard, High plausibility.

The use of BCG vaccine is contraindicated in patients with congenital or acquired immunodeficiency, including those with severe combined immunodeficiency, hypogammaglobulinemia or agammaglobulinemia, HIV infection, altered immune states (due to diseases such as leukemia, lymphoma, or generalized malignancy), or immunosuppression due to drug or other treatments (e.g., corticosteroids, alkylating agents, antimetabolites, or radiation). BCG vaccine contains live bacteria. The absence of immune competence may potentiate the replication of vaccine virus and cause a systemic BCG infection, which has been fatal in some cases. In addition, when used for immunization against tuberculosis, serum antibody response may be compromised. BCG vaccine should also not be administered to anyone with a family history of congenital or hereditary immunodeficiency until the individual's immune status can be assessed and is determined to be adequate.

References

  1. "Product Information. Tice BCG Vaccine (BCG vaccine)." Organon, West Orange, NJ.
Major

BCG vaccine (applies to TheraCys) infections

Major Potential Hazard, High plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral, Fever, Tuberculosis -- Active

The use of BCG vaccine is contraindicated in patients with fever unless the cause has been determined and evaluated. If the fever is due to an infection, administration of BCG vaccine should be deferred until the patient is afebrile and done with antimicrobial therapy. When BCG vaccine is used for immunization against tuberculosis, the presence of existing infection, especially if moderate or severe, may increase the risk of an adverse host reaction and/or vaccine failure. BCG vaccine is not for the treatment of active tuberculosis. When administered intravesically for the treatment of bladder cancer, concomitant antimicrobial therapy can interfere with the effectiveness of the vaccine. Antimicrobial therapy should be evaluated to assess the effects on BCG activity. Finally, since BCG vaccine contains live bacteria, it can potentially cause a systemic BCG infection, particularly in acutely ill patients. Disseminated BCG infection has been fatal in some cases.

References

  1. "Product Information. Tice BCG Vaccine (BCG vaccine)." Organon, West Orange, NJ.
Major

BCG vaccine (applies to TheraCys) urinary complications

Major Potential Hazard, High plausibility. Applicable conditions: Urinary Tract Infection

The use of BCG vaccine is contraindicated in patients with a urinary tract infection. Administration of the vaccine may result in the risk of disseminated BCG infection and/or an increased severity of bladder irritation, including hematuria, urinary frequency and dysuria.

References

  1. "Product Information. Tice BCG Vaccine (BCG vaccine)." Organon, West Orange, NJ.

TheraCys (bcg) drug interactions

There are 362 drug interactions with TheraCys (bcg)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.