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Trisenox Disease Interactions

There are 2 disease interactions with Trisenox (arsenic trioxide).

Major

Arsenic trioxide (applies to Trisenox) conduction abnormalities

Major Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias, Electrolyte Abnormalities

Arsenic trioxide can cause QTc interval prolongation, complete atrioventricular block, and a torsade de pointes- type ventricular arrhythmia, which can be fatal. Prior to initiating therapy with arsenic trioxide, assess the QTc interval by electrocardiogram, correct pre- existing electrolyte abnormalities, and consider discontinuing drugs known to prolong QTc interval. Arsenic trioxide should not be administered to patients with ventricular arrhythmia or prolonged QTc interval.

References

  1. "Product Information. Trisenox (arsenic trioxide)." Cephalon Inc PROD (2001):
Major

Arsenic trioxide (applies to Trisenox) encephalopathy

Major Potential Hazard, Moderate plausibility. Applicable conditions: Thiamine Deficiency, Malabsorption Syndrome, Alcoholism

Serious encephalopathy, including Wernicke's, has occurred in patients treated with arsenic trioxide injection. Wernicke's is a neurologic emergency. Consider testing thiamine levels in patients at risk for thiamine deficiency. Administer parenteral thiamine in patients with or at risk for thiamine deficiency. Monitor patients for neurological symptoms and nutritional status while receiving arsenic trioxide injection. If encephalopathy is suspected, immediately interrupt arsenic trioxide injection and initiate parenteral thiamine. Monitor until symptoms resolve or improve and thiamine levels normalize.

References

  1. "Product Information. Trisenox (arsenic trioxide)." Cephalon Inc PROD (2001):

Trisenox drug interactions

There are 283 drug interactions with Trisenox (arsenic trioxide).


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.