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Arginine/ascorbic acid/citrulline Disease Interactions

There are 5 disease interactions with arginine / ascorbic acid / citrulline.

Moderate

Arginine (applies to arginine/ascorbic acid/citrulline) electrolyte imbalances

Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Hyperkalemia, Diabetes Mellitus, Liver Disease

There have been reports of electrolyte imbalances including hyperkalemia with arginine infusions (especially at high doses). The risk may increase in patients with renal impairment, diabetes, and hepatic impairment. Caution is advised when used in these patients.

Moderate

Ascorbic acid (vitamin C) (applies to arginine/ascorbic acid/citrulline) hemolysis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Acute hemolysis following administration of high doses of ascorbic acid in patients with glucose-6-phosphate deficiency (G6PD) has been reported. Ascorbic acid should be administered cautiously and dosages modified in patients with G6PD.

References (1)
  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical
Moderate

Ascorbic acid (vitamin C) (applies to arginine/ascorbic acid/citrulline) kidney stones

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Nephrolithiasis

Large doses of ascorbic acid have lead to hyperoxaluria in 5% of patients. Ascorbic acid can acidify urine resulting in precipitation of urate, cystine, or oxalate stones. Ascorbic acid should be administered cautiously and dosages modified in patients predisposed to renal stones. Clinical monitoring of urinalysis for pH and crystal formation is recommended.

References (1)
  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical
Moderate

Ascorbic acid (vitamin C) (applies to arginine/ascorbic acid/citrulline) sodium

Moderate Potential Hazard, Low plausibility. Applicable conditions: Hypernatremia, Hypertension

Ascorbic acid preparations contain sodium. The sodium content should be considered when used in patients with sodium restricted diets and conditions require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

References (1)
  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical
Minor

Ascorbic acid (vitamin C) (applies to arginine/ascorbic acid/citrulline) dialysis

Minor Potential Hazard, High plausibility. Applicable conditions: hemodialysis

Ascorbic acid is removed by dialysis.

References (1)
  1. "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical

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Arginine/ascorbic acid/citrulline drug interactions

There are 75 drug interactions with arginine / ascorbic acid / citrulline.

Arginine/ascorbic acid/citrulline alcohol/food interactions

There is 1 alcohol/food interaction with arginine / ascorbic acid / citrulline.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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