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GenESA Disease Interactions

There are 3 disease interactions with GenESA (arbutamine).

Major

Dobutamine/arbutamine (applies to GenESA) arrhythmias

Major Potential Hazard, High plausibility. Applicable conditions: Hypertension

Dobutamine and arbutamine produce stimulation of the beta receptors of the heart. The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias. Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.

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Major

Dobutamine/arbutamine (applies to GenESA) hypotension

Major Potential Hazard, High plausibility. Applicable conditions: Dehydration

The use of dobutamine and arbutamine has been infrequently associated with significant hypotension especially in dehydrated patients secondary to beta-2 mediated vasodilation. Hypovolemia should be corrected before administering dobutamine or arbutamine. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.

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Major

Dobutamine/arbutamine (applies to GenESA) IHSS

Major Potential Hazard, High plausibility. Applicable conditions: Hypertrophic Cardiomyopathy

The use of dobutamine or arbutamine is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS). Dobutamine or arbutamine may increase the pressure gradient within the left ventricle and thereby worsen cardiac output in patients with IHSS.

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GenESA drug interactions

There are 67 drug interactions with GenESA (arbutamine).

GenESA alcohol/food interactions

There is 1 alcohol/food interaction with GenESA (arbutamine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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