Gleolan Disease Interactions
There are 3 disease interactions with Gleolan (aminolevulinic acid).
Aminolevulinic acid (applies to Gleolan) porphyria
Major Potential Hazard, Moderate plausibility.
The use aminolevulinic acid (ALA) oral solution is contraindicated in patients with acute or chronic types of porphyria, due to potential ineffectiveness of the drug in these patients.
Aminolevulinic acid (applies to Gleolan) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The effect of hepatic impairment on the pharmacokinetics of aminolevulinic acid (ALA) oral solution is unknown. The contribution of the liver to the elimination of ALA is unknown. ALA clearance may be reduced in patients with hepatic impairment. Care should be exercise when administering this agent in patients with liver impairment as it is not known if dose adjustment is needed.
Aminolevulinic acid (applies to Gleolan) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The effect of renal impairment on the pharmacokinetics of aminolevulinic acid (ALA) oral solution is unknown. Approximately one third of the ALA dose is excreted in urine as parent drug and drug clearance may be reduced in patients with renal impairment. Care should be exercise when administering this agent in patients with renal impairment as it is not known if dose adjustment is needed.
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Gleolan drug interactions
There are 134 drug interactions with Gleolan (aminolevulinic acid).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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