Edex (alprostadil) Disease Interactions
There are 3 disease interactions with Edex (alprostadil):
Alprostadil (applies to Edex) respiratory function
Major Potential Hazard, Moderate plausibility. Applicable conditions: Sepsis, Pulmonary Impairment
Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.
Alprostadil (applies to Edex) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect
Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.
Alprostadil (applies to Edex) hypotension
Moderate Potential Hazard, Moderate plausibility.
Increased peripheral blood levels of prostaglandin E1 (PGE1) and its metabolites can lead to hypotension and/or dizziness. Intracavernous injections of alprostadil can lead to increased blood levels of PGE1. Therapy with alprostadil should be administered cautiously in patients with hypotension.
- Linet OI, Ogrinc FG "Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction." N Engl J Med 334 (1996): 873-7
- "Intracavernous injection of alprostadil for erectile dysfunction." Med Lett Drugs Ther 37 (1995): 83-4
Edex (alprostadil) drug interactions
There are 30 drug interactions with Edex (alprostadil)
More about Edex (alprostadil)
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- Drug class: impotence agents
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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