Abacavir Disease Interactions
There are 2 disease interactions with abacavir:
NRTIs (Includes abacavir) ↔ hepatotoxicity
Major Potential Hazard, Moderate plausibility. Applies to: Alcoholism, Liver Disease
Hepatotoxicity including lactic acidosis, severe hepatomegaly with steatosis, fulminant hepatitis, and hepatic failure has been associated with the use of some nucleoside reverse transcriptase inhibitors (NRTIs) alone or in combination with other antiretroviral agents. Therapy with NRTIs should be administered cautiously in patients with preexisting liver disease, a history of alcohol abuse, or hepatitis. Therapy should be suspended if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur. The use of abacavir is contraindicated in patients with moderate to severe hepatic impairment as its safety and efficacy has not been established on these patients.
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- Miller KD, Cameron M, Wood LV, Dalakas MC, Kovacs JA "Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases." Ann Intern Med 133 (2000): 192-6
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- "Product Information. Ziagen (abacavir)." Glaxo Wellcome, Research Triangle Pk, NC.
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- "Product Information. Viread (tenofovir)." Gilead Sciences, Foster City, CA.
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Abacavir (Includes abacavir) ↔ cardiovascular disease
Moderate Potential Hazard, Moderate plausibility. Applies to: History - Myocardial Infarction, Hypertension, Hyperlipidemia, Diabetes Mellitus
Some clinical trials have reported increased risk of myocardial infarction in patients treated with abacavir. Although some of the findings are inconclusive, as a precaution, the underlying risk of coronary heart disease should be assessed before therapy, and action should be taken to minimize all modifiable risk factors such as hypertension, hyperlipidemia, diabetes mellitus, smoking, etc.
Abacavir drug interactions
There are 40 drug interactions with abacavir
Abacavir alcohol/food interactions
There are 3 alcohol/food interactions with abacavir
More about abacavir
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- Drug class: nucleoside reverse transcriptase inhibitors (NRTIs)
- FDA Alerts (3)
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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