Abacavir Disease Interactions
There are 2 disease interactions with abacavir:
Nrtis (Includes Abacavir) ↔ Hepatotoxicity
Severe Potential Hazard, Moderate plausibility
Applies to: Alcoholism, Liver Disease
Hepatotoxicity including lactic acidosis, severe hepatomegaly with steatosis, fulminant hepatitis, and hepatic failure has rarely been associated with the use of nucleoside reverse transcriptase inhibitors (NRTIs) alone or in combination with other antiretroviral agents. Therapy with NRTIs should be administered cautiously in patients with preexisting liver disease, a history of alcohol abuse, or hepatitis. Therapy should be suspended if clinical or laboratory findings suggestive of lactic acidosis or pronouced hepatotoxicity occur.
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Abacavir (Includes Abacavir) ↔ Cardiovascular Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: Cardiovascular Disease, History - Myocardial Infarction, Hypertension, Hyperlipidemia, Diabetes Mellitus
Some clinical trials have reported increased risk of myocardial infarction in patients treated with abacavir. Although some of the findings are inconclusive, as a precaution, the underlying risk of coronary heart disease should be assessed before therapy, and action should be taken to minimize all modifiable risk factors such as hypertension, hyperlipidemia, diabetes mellitus, smoking, etc.
abacavir drug Interactions
There are 39 drug interactions with abacavir
abacavir alcohol/food Interactions
There are 3 alcohol/food interactions with abacavir
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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