Ziagen (abacavir) Disease Interactions
There are 2 disease interactions with Ziagen (abacavir):
Nrtis (Includes Ziagen) ↔ Hepatotoxicity
Severe Potential Hazard, Moderate plausibility
Applies to: Alcoholism, Liver Disease
Hepatotoxicity including lactic acidosis, severe hepatomegaly with steatosis, fulminant hepatitis, and hepatic failure has rarely been associated with the use of nucleoside reverse transcriptase inhibitors (NRTIs) alone or in combination with other antiretroviral agents. Therapy with NRTIs should be administered cautiously in patients with preexisting liver disease, a history of alcohol abuse, or hepatitis. Therapy should be suspended if clinical or laboratory findings suggestive of lactic acidosis or pronouced hepatotoxicity occur.
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- "Product Information. Viread (tenofovir)." Gilead Sciences, Foster City, CA.
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- Pai VB, Koranyi K, Nahata MC "Acute hepatitis and bleeding possibly induced by zidovudine and ritonavir in an infant with HIV infection." Pharmacotherapy 20 (2000): 1135-40
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- Miller KD, Cameron M, Wood LV, Dalakas MC, Kovacs JA "Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases." Ann Intern Med 133 (2000): 192-6
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- "Product Information. HIVID (zalcitabine)." Roche Laboratories, Nutley, NJ.
- Kronenberg A, Riehle HM, Gunthard HF "Liver failure after long-term nucleoside antiretroviral therapy." Lancet 358 (2001): 759-601
- Coghlan ME, Sommadossi JP, Jhala NC, Many WJ, Saag MS, Johnson VA "Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases." Clin Infect Dis 33 (2001): 1914-21
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- "Product Information. Videx (didanosine)." Bristol-Myers Squibb, Princeton, NJ.
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Abacavir (Includes Ziagen) ↔ Cardiovascular Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: History - Myocardial Infarction, Hypertension, Hyperlipidemia, Diabetes Mellitus
Some clinical trials have reported increased risk of myocardial infarction in patients treated with abacavir. Although some of the findings are inconclusive, as a precaution, the underlying risk of coronary heart disease should be assessed before therapy, and action should be taken to minimize all modifiable risk factors such as hypertension, hyperlipidemia, diabetes mellitus, smoking, etc.
Ziagen (abacavir) drug Interactions
There are 45 drug interactions with Ziagen (abacavir)
Ziagen (abacavir) alcohol/food Interactions
There are 3 alcohol/food interactions with Ziagen (abacavir)
More about Ziagen (abacavir)
- Ziagen Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- Generic Availability
- Drug class: nucleoside reverse transcriptase inhibitors (NRTIs)
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.