Medically reviewed on June 7, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Thrombolytic
Pharmacologic Class: Tissue Plasminogen Activator
Uses For This Medicine
Tenecteplase is used to dissolve blood clots that have formed in the blood vessels of the heart and seriously lessen the flow of blood in the heart. Tenecteplase is used to improve survival after a heart attack.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tenecteplase, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to tenecteplase or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Children—Studies on tenecteplase have been done only in adult patients, and there is no specific information comparing use of tenecteplase in children with use in other age groups.
The need for treatment with tenecteplase may be increased in elderly patients with blood clots. However, the chance of bleeding may also be increased. It is especially important that you discuss the use of tenecteplase with your doctor.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving tenecteplase, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using tenecteplase with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using tenecteplase with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alteplase, Recombinant
- Dabigatran Etexilate
- Pentosan Polysulfate Sodium
- Protein C
- Reteplase, Recombinant
Using tenecteplase with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical Problems
The presence of other medical problems may affect the use of tenecteplase. Make sure you tell your doctor if you have any other medical problems, especially:
- Blood disease, bleeding problems, or a history of bleeding in any part of the body or
- Brain disease or tumor or
- Heart or blood vessel disease, including irregular heartbeat or
- High blood pressure or
- Liver disease or
- Stroke—The chance of bleeding may be increased
- Infection—Chance of spreading the infection into the blood stream
Also, tell your doctor if you have recently had any of the following conditions:
- Falls or blow to the body or head or any other injury or
- Injections into a blood vessel or
- Placement of any tube into the body or
- Surgery of any kind, including dental surgery—The chance of serious bleeding may be increased
If you have recently had a baby, use of tenecteplase may cause serious bleeding.
Proper Use of This Medicine
The dose of tenecteplase will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of tenecteplase. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Precautions While Using This Medicine
Tenecteplase can cause bleeding that usually is not serious. However, serious bleeding may occur in some people. To help prevent serious bleeding, carefully follow any instructions given by your health care professional. Also, move around and be handled as little as possible, and do not get out of bed on your own, unless your health care professional tells you it is all right to do so.
Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines, such as aspirin.
This Medicine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Bleeding or bruising of any kind, especially around the place of injection
- collection of blood under skin
Less common or rare
- Abdominal or stomach pain or swelling
- back pain or backaches
- blood in throat
- blood in urine
- bloody or black, tarry stools
- coughing up blood
- difficulty swallowing
- fast, slow or irregular breathing
- fast, slow or irregular heartbeat
- shortness of breath and/or wheezing
- skin rash, hives or itching
- swelling of eyes, face, lips, or tongue
- tightness in chest
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bloody nose
- unexplained nosebleeds
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about tenecteplase
- Tenecteplase Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
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- Drug class: thrombolytics
Other brands: TNKase