Medically reviewed by Drugs.com. Last updated on Jan 25, 2022.
Commonly used brand name(s)
In the U.S.
- Sterile Saline Diluent Tip-Lok Syringe
Available Dosage Forms:
Therapeutic Class: Parenteral Electrolyte, Sodium
Uses for sodium chloride
Sodium chloride 23.4% injection is used to replenish lost water and salt in your body due to certain conditions (eg, hyponatremia or low salt syndrome). It is also used as an additive for total parenteral nutrition (TPN) and carbohydrate-containing IV fluids.
Sodium chloride is to be given only by or under the supervision of your doctor.
Before using sodium chloride
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sodium chloride, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to sodium chloride or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of sodium chloride 23.4% injection in the pediatric population. Safety and efficacy have not been established.
No information is available on the relationship of age to the effects of sodium chloride 23.4% injection in geriatric patients.
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of sodium chloride. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or
- Congestive heart failure or
- Epilepsy (seizures) or
- Heart or blood vessel disease or
- Hypertension (high blood pressure) or
- Kidney disease, severe or
- Liver disease (eg, cirrhosis)—Use with caution. May make these conditions worse or increase the chance of side effects occurring.
- Fluid retention (swelling) or
- Hypernatremia (high sodium in the blood)—Should not be used in patients with these conditions.
- Kidney disease—Use with caution. Sodium chloride 23.4% contains aluminum, which may be toxic. The effects may be increased because of the slower removal of the medicine from the body.
Proper use of sodium chloride
A nurse or other trained health professional will give you sodium chloride in a medical facility. It is given through a needle placed into one of your veins after it has been diluted.
During the procedure, you will be awake and be asked questions about how you are doing by the health care team. This helps them to react quickly to any problems you might have and to keep side effects to a minimum.
Precautions while using sodium chloride
It is very important that your doctor check your progress closely while you are receiving sodium chloride to make sure that the medicine is working properly and to check for unwanted effects.
Sodium chloride may cause serious problems (eg, hypokalemia, acidosis, heart failure, pulmonary edema, or fluid retention) and are more likely to occur if sodium chloride is given for a long time or in high doses. Talk to your doctor if you have concerns.
Sodium chloride side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Excessive blood loss
- burning pain in lower abdomen
- chest pain, severe
- feeling of heat
- feeling of warmth in the lips and tongue
- headache (severe or dull)
- loss of consciousness
- numbness of the fingertips
- pain in lower back, pelvis, or stomach
- ringing in the ears
- thirst (sudden) or salty taste
- vision problems
Incidence not known
- Bad smelling discharge from the vagina
- bleeding or redness at the injection site
- decrease in the amount of urine
- decreased urine output
- dilated neck veins
- extreme tiredness or weakness
- full or bloated feeling
- increase in bleeding from the uterus
- irregular breathing or heartbeat
- pain in the lower abdomen
- passing of pieces of tissue from the uterus
- pressure in the stomach
- stomach cramping
- swelling of the abdominal or stomach area
- swelling of the face, fingers, feet, or lower legs
- tightness in the chest
- troubled breathing
- weight gain
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
- usual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Loss of appetite
- weight loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about sodium chloride
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.