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Plasminogen, human-tvmh (Intravenous)

Medically reviewed by Last updated on Sep 28, 2022.

Commonly used brand name(s)

In the U.S.

  • Ryplazim

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Blood Modifier Agent

Uses for plasminogen, human-tvmh

Plasminogen, human-tvmh injection is used to treat plasminogen deficiency type 1 (hypoplasminogenemia). It works by increasing the plasminogen levels in the blood.

Plasminogen, human-tvmh is to be given only by or under the supervision of your doctor.

Before using plasminogen, human-tvmh

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For plasminogen, human-tvmh, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to plasminogen, human-tvmh or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of plasminogen, human-tvmh injection in children 11 months of age and older. Safety and efficacy have been established.


Appropriate studies have not been performed on the relationship of age to the effects of plasminogen, human-tvmh injection in geriatric patients. Elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving plasminogen, human-tvmh.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of plasminogen, human-tvmh. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding, active or
  • Blood clots or
  • Kidney disease or
  • Lung or breathing problems or
  • Stomach or bowel problems—Use with caution. May make these conditions worse.

Proper use of plasminogen, human-tvmh

A nurse or other trained health professional will give you plasminogen, human-tvmh in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle should remain in place for 10 to 30 minutes. Plasminogen, human-tvmh is usually given every 2 to 4 days.

Plasminogen, human-tvmh comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Precautions while using plasminogen, human-tvmh

It is very important that your doctor check your progress closely while you are receiving plasminogen, human-tvmh. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be symptoms of bleeding problems.

Plasminogen, human-tvmh may cause tissue sloughing or shedding, which may cause breathing problems, stomach or bowel problems, or urinating problems. Check with your doctor right away if you have blood in the urine or stools, cough or hoarseness, lower back or side pain, sore throat, trouble breathing, or voice changes.

Plasminogen, human-tvmh may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, skin rash, trouble breathing, or unusual tiredness or weakness.

Plasminogen, human-tvmh is made from donated human blood. Some human blood products have transmitted certain viruses (eg, Creutzfeldt-Jacob disease) to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you have concerns about this risk.

Before you have any medical tests, tell the medical doctor in charge that you are taking plasminogen, human-tvmh. The results of some tests may be affected by plasminogen, human-tvmh.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Plasminogen, human-tvmh side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Bleeding gums
  • bloating
  • constipation
  • coughing up blood
  • difficulty in breathing or swallowing
  • dizziness
  • headache
  • increased menstrual flow or vaginal bleeding
  • nausea
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • stomach pain

Incidence not known

  • Chest pain or tightness
  • cough or hoarseness
  • fast heartbeat
  • hives, itching, skin rash
  • lower back or side pain
  • lower stomach pain
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sore throat
  • unusual tiredness or weakness
  • voice changes
  • vomiting of blood or material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back, arm, or leg pain
  • difficulty in moving
  • dry mouth
  • muscle pain or stiffness
  • pain in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

More about plasminogen

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.