Generic Name: voxelotor (vox-EL-oh-tor) (Oral route)
Medically reviewed by Drugs.com. Last updated on Oct 14, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Blood Modifier Agent
Uses for Oxbryta
Voxelotor is used to treat patients with sickle cell disease. Sickle cell disease is an inherited blood disorder in which the red blood cells are abnormally shaped (crescent or sickle shape), that resulted from a mutation in the gene for hemoglobin. Voxelotor works by keeping the hemoglobin in an oxygenated state, thus helping the red blood cells maintain a normal shape and preventing them from binding together and blocking the flow in the blood vessels.
This medicine is available only with your doctor's prescription.
Before using Oxbryta
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of voxelotor in children 12 years of age and older. However, safety and efficacy have not been established in children younger than 12 years of age.
Appropriate studies on the relationship of age to the effects of voxelotor have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- St John's Wort
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Liver problems, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of Oxbryta
Take this medicine exactly as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. This medicine is for a long-term treatment.
This medicine usually comes with patient information leaflet. Read and follow the instructions carefully and make sure you understand them before taking this medicine. If you have any questions, ask your doctor.
Swallow the tablet whole. Do not crush, break, or chew it.
Take this medicine at the same time each day, with or without food.
Your doctor may want you to take hydroxyurea (Hydrea®) while you are taking this medicine.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For sickle cell disease:
- Adults and children 12 years of age and older—1,500 milligrams (mg) once a day.
- Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For sickle cell disease:
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using Oxbryta
It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
This medicine may cause allergic reactions. Tell your doctor right away if you have a rash or itching skin, chest pain, fever or chills, mild swelling of the face, trouble breathing, or unusual tiredness or weakness while using this medicine.
Do not change your dose or stop taking this medicine without checking first with your doctor.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Oxbryta side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Black, tarry stools
- chest pain
- hives or welts, itching or skin rash
- painful or difficult urination
- redness of the skin
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face
- swollen glands
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- stomach pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about Oxbryta (voxelotor)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 3 Reviews
- Drug class: miscellaneous uncategorized agents
- FDA Approval History
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