floxuridine (Injection route)
All patients should be hospitalized for initiation of the first course of therapy with floxuridine because of the possibility of severe toxic reactions .
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Antimetabolite
Uses For floxuridine
Floxuridine belongs to the group of medicines known as antimetabolites. It is used to treat some kinds of cancer.
Floxuridine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by floxuridine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.
Before you begin treatment with floxuridine, you and your doctor should talk about the good floxuridine will do as well as the risks of using it.
Floxuridine is to be administered only by or under the immediate supervision of your doctor.
Before Using floxuridine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For floxuridine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to floxuridine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
There is no specific information comparing use of floxuridine in children with use in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing use of floxuridine in the elderly with use in other age groups, floxuridine is not expected to cause different side effects or problems in older people than it does in younger adults.
|All Trimesters||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of floxuridine. Make sure you tell your doctor if you have any other medical problems, especially:
- Chickenpox (including recent exposure) or
- Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body
- Hepatitis (history of)—Increased risk of hepatitis
- Kidney disease or
- Liver disease (other)—Effects of floxuridine may be increased because of slower removal from the body
- Infection—Floxuridine can decrease your body's ability to fight infection
Proper Use of floxuridine
Floxuridine sometimes causes nausea and vomiting. Tell your doctor if this occurs, especially if you have stomach pain.
The dose of floxuridine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of floxuridine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Precautions While Using floxuridine
It is very important that your doctor check your progress at regular visits to make sure that floxuridine is working properly and to check for unwanted effects.
While you are being treated with floxuridine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Floxuridine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
floxuridine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- sores in mouth and on lips
- stomach pain or cramps
- Black, tarry stools
- nausea and vomiting
- scaling or redness of hands or feet
- swelling or soreness of the tongue
- Blood in urine or stools
- cough or hoarseness
- fever or chills
- lower back or side pain
- painful or difficult urination
- pinpoint red spots on skin
- trouble in walking
- unusual bleeding or bruising
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common or rare
- Loss of appetite
- skin rash or itching
floxuridine sometimes causes temporary thinning of hair. After treatment with floxuridine has ended, normal hair growth should return.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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More about floxuridine
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- Drug class: antimetabolites
Other brands: FUDR