Latuda and Vomiting: What Users Say

• The...
• Taken for 1 to 6 months
• December 30, 2019

For Bipolar Disorder "Latuda has been a game changer for me. I am a functioning, highly anxious, super bipolar human. I have taken a lot of different meds over the years including Seroquel, Lamictal, Zyprexa, and Risperdal, all of which caused extreme fatigue and minor weight gain. Since taking Latuda, the little bit of weight came off and my mood has mostly stabilized. The only downside that I have found is that if I take it on an empty stomach in the a.m. and skip breakfast, nausea and vomiting are almost guaranteed. Sometimes I'm not in the mood to eat when I wake up but meh. Take it at night I guess to avoid that. I would recommend Latuda to anyone with Bipolar disorder as it has brought me many positive changes."

• Ano...
• October 12, 2014

For Bipolar Disorder "It's been a love-hate relationship with Latuda for me. After 2 months of using it, I noticed a significant change in my depression, which was fantastic. But, I experience SEVERE nausea even when I eat enough food. I have even thrown up about 6 or 7 times within my 7 months of taking it. Which is unpleasant to say the least. The nausea usually sets in about 30-45 minutes after taking and lasts anywhere from 5 minutes to an hour."

• Ssa...
• Taken for 2 to 5 years
• October 8, 2019

For Bipolar Disorder "I began taking Latuda several years ago, and it has been the best treatment for my bipolar depression. It keeps my mood up without causing mania. However, the key for me was in the dosing. I have always been more sensitive to drugs than other people, side effects are stronger, some drugs knock me out, and with surgeries, anesthesia always makes me vomit, etc. I take 40 mg of Latuda, and it works best. My doctor increased it to 60 mg because it's closer to the 'therapeutic dose.' That was too much for me. I was jittery, couldn't sit still, felt like racing in my chest, it was a strange sensation. But when I went back down to 40 mg, I was fine, and it's enough to treat my mood. If you're like me, be careful of taking too much and find a doctor who is willing to listen about lowering doses. It works so well for me, my doctor gives me samples since I can't afford the high copays."

• Gee...
• October 6, 2016

For Bipolar Disorder "I switched this from Abilify, and the difference is night and day - energized, happy, and manic-free. I follow the rules to a tee - take at night with a minimum of 350 calories - I noticed some posts here reporting vomiting and ineffectiveness - it's not just about stomach upset - you MUST take the med on a full stomach or it won't be absorbed properly and will likely cause upset too - this is what my doc tells me, and he seems to be right."

• Gra...
• October 31, 2015

For Bipolar Disorder "The first time I took Latuda was in the hospital, and I was put on 40 mg. I had a little nausea, but no other side effects. Later, my psychiatrist raised the dose to 80 mg. That's when I started having severe akathisia and vomiting (no weight gain or loss, though). It seemed almost intolerable, but I stuck with it for several months. I then switched to Abilify but soon was taken off antipsychotics altogether. I was stable for several months, but then started having mania again. Recently, my psychiatrist recommended that I try Latuda at a smaller dose. I was skeptical, but I decided to try it. I love it! The dose is just enough to control my symptoms, and I've had no side effects. My new insurance is denying it, though, so I'm on samples."

• Anonymous
• October 17, 2011

For Bipolar Disorder "I am taking 900 mg of lithium for bipolar and Seroquel. I was on 600 mg, and it made me gain 20 pounds in 3 weeks, so I got off, also due to high cholesterol. I was put on Latuda last week. I threw up the first two days taking it, and it was hell, but now I'm used to it and feel calm and sleep better. So far, so good. Stopped gaining, and now I don't care to eat as much. GREAT."

• Win...
• May 3, 2019

For Bipolar Disorder "Because of Latuda, I now have side effects of constant restlessness. I'm always sleepy, I have uncontrollable facial movements, teeth grinding, blinking excessively at times, very dizzy a lot of the time and lightheaded, lots of nausea and vomiting, major loss of appetite. I lost 40 lbs, inability to keep still most of the time, agitation, blurred vision, no sex drive, confused, dry skin, stiff neck, I can't turn all the way, twitching uncontrollably of my eyes, mouth, tongue, face, arms, legs, lips. My back is always sore, my anxiety attacks are worse. I'm hyperactive, I feel manic all the time, always feel nervous. I have tightening of my jaw and snapping, and I even chipped a tooth. Constant headaches, back lower skull always tense, trouble collecting my words, weird jerking movements from my fingers, toes, arms, legs, face, lips, mouth, tongue, and eyes. Unsure of what to do next, restless, confused, looking for something to do constantly. I always feel weak, sweating of my hands and feet. And it won't go away!!"

• Har...
• Taken for 2 to 5 years
• June 22, 2023

For Bipolar Disorder "The withdrawal is horrific if you already have akathisia. One of the biggest side effects is akathisia, and no one talks about it. I had akathisia from coming off meds cold turkey. Before being put on Latuda, I was rapidly tapered off all my meds and given no time to adjust. The guy started Latuda along with another cocktail. I’ve been diagnosed as bipolar with depressive episodes. I’ve never been psychotic or had mania or even hypomania. The doctor tapered me too fast off Latuda, and now I have all kinds of issues. New symptoms include grinding of teeth, jaw clenching, cracking jaw, flu-like symptoms, nausea, vomiting, muscle aches, muscle twitches and spasms, itching, headaches/migraines, diarrhea, irritability, fatigue, chills/sweats, brain fog, and more. My symptoms of akathisia and insomnia are unbearable now after being tapered too fast."

• Anonymous
• September 6, 2012

For Bipolar Disorder "Some nausea, severe vomiting when I first began... better now. It knocks me out pretty quick, so I take it at night along with 300 mg of Lamictal and 150 mg of Trazodone. The worst side effect I've noticed is extreme fatigue. I can't seem to get enough sleep. Otherwise, it's definitely a step in the right direction. Two weeks and counting - if the fatigue thing doesn't let up, I'll probably have to stop it and move on to something else (it's that bad). Also, curbs my appetite considerably."

• kk1...
• Taken for 2 to 5 years
• October 24, 2015

For Bipolar Disorder "I started taking Latuda in 2014 after I went off Lithium, and Lamotrigine just wasn't helping my depression side. Right away, I noticed a difference. I think ever since, my life has been doing well. I'm doing well in my professional life. I think of suicide very little now. I still have my ups and downs at times, though, and I think a lot of it has to do with not eating right and exercising. When I do those things and take Latuda, I feel great. The only thing I don't like about Latuda is if you don't take it with enough food (vegetables are not enough, you need something starchy, at least 350 calories), you vomit or feel really sick. It feels like something foreign in your body. And it also makes me so tired! Sometimes I actually feel a little scared."

• Wen...
• November 20, 2015

For Bipolar Disorder "I have been dealing with mental health issues since I was about 19 years old and am 45 now. I have been on numerous medications, too many to count, and I started taking Latuda about 3 weeks ago. I also take Trileptal, Lamictal, lithium, Prozac, and Vyvanse, and I can't begin to tell you how much better I feel. It just amazes me. I haven't snapped at anyone in a couple of weeks, my mood is the most stable it's been in 20 years. I actually like to be around people again. I'm not full of hate and anger. I have dealt with some serious nausea, vomiting, and headaches, so it is very important to eat at least the recommended amount of calories, and it's much better if I take it at night. I am very grateful I was willing to try Latuda. Thank you."

• Cou...
• Taken for 1 to 6 months
• July 18, 2017

For Bipolar Disorder "I was on Seroquel for quite some time and really liked it, but I didn't appreciate the small weight gain or my lack of desire to wake up in the morning. However, it stabilized my mood and gave me the best sleep of my life. My doctor suggested Latuda, which I've been taking for about 5 months now at 60 mg. Latuda is also great at stabilizing my mood and no weight gain, but it makes me terribly sick. I'm very nauseous even when I have food in my stomach-sometimes to the point I'm sure I'm going to vomit. It even makes my teeth hurt initially. I want to love this medication as it is truly helpful in mood stabilization, but the induced sickness every time I take it is getting old."

• Mcd...
• July 22, 2017

For Bipolar Disorder "Glad works for some. I had nausea, vomiting taking it with food. Panic attacks with racing heart rate, which I've never had before. Muscle dyskinesia of jaw. What made it worse was because it wasn't helping my depression, my psych kept upping the dose 'to see' if that worked. Worst drug I've ever been on & hope your caretakers pay attention to your side effects."

• All...
• Taken for 1 to 2 years
• October 1, 2018

For Schizophrenia "I hate Latuda medication. I've been on this drug for about a year now. I started getting nauseous when I first started, now I'm getting vomiting and diarrhea every day, getting worse. I've been and had blood tests and an ultrasound on my stomach, nothing physically wrong with me. I advise anyone considering taking Latuda should think twice about side effects like mine. This experience is so serious I can't believe they invented a medication that mucks up your physical health. Cheers."

• JML...
• Taken for 1 to 6 months
• August 30, 2016

For Bipolar Disorder "Bipolar 2 cyclic. Started with Seroquel, Lamictal, and Vyvanse. Seroquel worked but horrible side effects: urine retention, daily headache, all-day-long nausea, weight gain 22#. Despite watching diet and daily swim. Started Latuda. Took 40 mg at dinner (8 pm) for 4 weeks. What a great mood stabilizer for me, but still having periodic days of mania and depression. Increased to 80 mg. Doing great. Within 3 weeks of starting Latuda, lost 20 lbs (almost like my metabolism kicked into overdrive) after being on Seroquel. Side effects: my stomach is super sensitive, so of course nausea. I must take 1 hour after dinner, letting food digest, no alcohol. Otherwise, vomiting within 2 hours after taking. I take RX Haldol 0.5 mg BID and Zofran ODT for breakthrough nausea."

• Emm...
• November 21, 2015

For Schizophrenia "I have been taking 60 mg for schizoaffective disorder. Have come off flupenthixol and am now coming off Seroquel. Best I've felt in years. Much happier. Delusions are gone, not hearing voices or misinterpreting things. I take it in the morning with food but have found when I drink Jamaican tea I throw up and have a sore stomach at night. Have switched to decaf tea with lemon juice."

• Nug...
• May 7, 2017

For Bipolar Disorder "I have bipolar 2. Lamotrigine 400 mg of lamotrigine has taken away anger and irritability. I was still crying over everything, so my psychiatrist put me on Latuda 20 mg for 1 month. First week, projectile vomiting every other day for a week. Saw no benefit. I was bumped to 40. Immediately, I felt semi-anxious. Day 5, almost had a panic attack out of the blue. This med is not right for me. It really scared me how anxious and panicky I became on 40 mg. I am stopping after I call my doctor."

• Awa...
• Taken for 1 to 2 years
• September 13, 2017

For Bipolar Disorder "I took Latuda for a little over a year, and I had so many side effects. I was so tired all the time, I couldn't function at work, and I was a cashier. My throat got smaller, I would gag brushing my teeth, and I used to be able to take three pills at once without a problem. When I was on Latuda, I could barely swallow one, and I still gagged. I had memory loss and weight gain. I was miserable, and I couldn't figure out why. Then I realized that it was Latuda. So, I got weaned off of it, and I felt ten million times better. I lost fifty pounds since I've been off of it, I can function again, my memory is slowly coming back, and I don't gag when I brush my teeth, and I can swallow more than one pill without gagging."

• BiP...
• Taken for 1 to 6 months
• December 10, 2016

For Bipolar Disorder "I started Latuda after being on Abilify since 2004. I was taken off Abilify because I began vomiting every day and had severe rashes after being on the drug for about twelve years. Latuda is horrible! Mind you, I haven't actually had a serious psychiatrist sit down and actually understand my symptoms or who I am in about five years... seems as if that is nonexistent in my region or something now? I developed severe migraines on Latuda and have had more frequent seizures on this medication. The doctor I have seen one time this entire year doesn't want to work with me even though he even noticed I am extremely agitated and annoyed all the time on this medication. I used to be very calm and easygoing; however, now everything irritates me."

• Cik...
• April 30, 2016

For Bipolar Disorder "I am taking 750 mg of lithium and 450 mg of amisulpride with 80 mg of Latuda. I am reducing my amisulpride by 50 mg every week until I eventually come off it. My mom has noticed that my face has become brighter using Latuda. I experience nausea sometimes with Latuda, I need to eat over 350 calories to not have nausea. I can't eat creamy foods with it, otherwise, I vomit. I'm hoping I don't go manic and relapse when I fully come off amisulpride."

• SS2...
• May 14, 2016

For Bipolar Disorder "Worked great for my 13-year-old with schizoaffective disorder for 8 months, the only side effect was vomiting a few minutes after taking it at times. Zantac seemed to help for a while, but the vomiting became more frequent, so ultimately he had to come off of it. It seemed to work well, though, with no restlessness, akathisia, or any other side effects. He took it with lithium, so it might have been the combination that was too much for his stomach."

• tda...
• Taken for 1 to 6 months
• July 13, 2017

For Bipolar Disorder "My experience with Latuda is mostly negative. I have been on it for 5 months and will be tapering off in a couple of weeks, thankfully. The only good thing about it is it stabilized me in a severe mixed mania with a psychosis episode, but other than that, the side effects are horrible. It has done nothing for my depression the past two months, and I have had anxiety and major irritability on it. The nausea and vomiting are miserable. I was prescribed Zofran to offset the nausea, but that is not so helpful either since the Zofran causes constipation. The 350 calorie requirement is a pain because you can't take it with dinner or you fall asleep instantly, so I take it with a late-night meal to last a few more hours, hence more weight gain."

• swe...
• Taken for 1 to 6 months
• January 3, 2019

For Bipolar Disorder "I always had problems tolerating Latuda. When I started on 20 mg, it used to put me right to sleep. Then, when I was increased to 40 mg, I had the worst nausea, they had to split my dose so I could tolerate it. It seemed to work, so I toughed it out. I got all the way up to 80 mg and even tried 100 mg, but it made me vomit every time I took it. I’m currently tapering off of it because the nausea is unbearable now. The other thing I hate about it is the caloric requirement. It makes me so nauseous I don’t have an appetite and then have to force myself to eat 350 cals. Wasn’t worth it, glad to be getting off of it."

• Jom...
• Taken for 1 to 6 months
• September 24, 2016

For Bipolar Disorder "Update on Haldol and Zofran ODT. MD increased my dose of Latuda from 80 mg to 120 mg. After 1 hour of taking Latuda, I got violent, severe vomiting daily for 8 days despite the use of antiemetics. I told the MD I quit, no illness is worth this. He suggested 40 mg in the AM and 80 mg in the PM. So here is my regimen: Upon awakening, take 0.5 mg Haldol, after 1 hour eat minimum requirements 350 calories (to make Latuda work best), then take Zofran 4 mg ODT and wait 20 minutes and take Latuda. Repeat in PM. No nausea/vomiting for 7 days - yeah. Hoping this will last because I'm running out of drugs to use and Latuda has worked best. Also on Lamictal and Vyvanse for cyclic bipolar (diagnosed when I was 60!)."

• Fan...
• September 19, 2015

For Bipolar Disorder "I have been taking this at 20 mg for a week and have gone from decent to violently ill ... vomiting, the runs, crippling headaches, muscle pain ... I stopped taking it today, slowly starting to feel better..."