Guaifenesin / pseudoephedrine User Reviews & Ratings

Brand names: Mucinex D, Mucus Relief D, Entex PSE, Entex T, GP 500, Mucus D, Mucinex D Maximum Strength, Decongest II, Desal II, Dynex, Despec-SR, Nalex CR, Mardrops-EX, Congestac, Poly-Vent IR, Despec-Tab, Guaimax-D, Anatuss LA, Fenex-PSE, G-Phed, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Guaivent PD, Guaibid D Pediatric, Eudal SR, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Deco-D, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Ami-Tex PSE, Ru-Tuss DE Guaifenex RX Guaitab Guiatuss PE Degen II Guaivent (Ethex) Tusnel Pediatric Drops Altarussin PE Sinutab Non Drying Robitussin Severe Congestion Humibid GC Guaifenex GP ExeFen-IR Durasal II Guiadrine PSE Guiatex II SR Coldmist Drituss GP Coldmist LA Coldmist Jr Ambifed-G Guaifenex PSE 80 Aldex GS Guaifenex PSE 85 Maxifed ExeFen Ambi 60/1000 Ambi 60/580 Ambi 80/780 Aquatab D Dose Pack …show all brand names

Guaifenesin / pseudoephedrine has an average rating of 6.1 out of 10 from a total of 252 reviews on Drugs.com. 48% of reviewers reported a positive experience, while 29% reported a negative experience.

Condition	Avg. Rating	Reviews	Compare
Cough and Nasal Congestion	6.1	252 reviews for Cough and Nasal Congestion	1166 medications
Add your review

Reviews for Guaifenesin / pseudoephedrine

Kagard
January 2, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Took 1 Mucinex DM around 6 PM. My experience is like many here. It worked great on my congestion, but it is midnight and I am wide awake. I found this site searching for "Does Mucinex DM keep you awake?" Yup, it does."

7 / 10

Was this helpful?Yes No

73 Report

cloworm
April 23, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I read the reviews on Mucinex and was a little concerned but I was also desperate. For 2 months I had a thick post nasal drip that would cause me to constantly cough, especially at night. I had to sleep sitting up in my chair in the living room. I was wheezing, runny nose, coughing up tons of mucus or clearing my throat from it. I took one tablet at 8 am and another tablet at 8 pm. OMG I can clearly breathe with no wheezing or congestion or mucus getting in my way. I slept through the night and when I woke up my nasal passages and throat were clear. "

9 / 10

Was this helpful?Yes No

71 Report

Pleas...
Taken for 2 to 5 years
July 3, 2019

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I'm a 37 year old male. I've taken Mucinex D at some point each winter for the last few years; typically to help with a lingering cough/mucus after a nasty head cold. Taken as directed it works well for me, though I do get some of the racing heart/anxious feeling others have reported it does not keep me awake at night. One surprising side effect, is that every time I am on this medicine I become like a porn-star. I can make love to my wife for a solid 45 minutes to an hour before ejaculating. I don't know what particular ingredient in this medicine would cause that, but I've experienced it a handful of times."

Was this helpful?Yes No

35 Report

Breflex
Taken for less than 1 month
February 2, 2020

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I have been laying here all night after taking Mucinex D. My brain won’t shut down. I am wide awake. Mucinex D does help with nasal congestion. I do not have the jitters or the racing heart. After reading the other reviews,I know now why I can’t sleep. UGH!"

7 / 10

Was this helpful?Yes No

30 Report

Anonymous
Taken for less than 1 month
August 19, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I have bronchitis was coughing non stop with chest congestion. I bought a package of Mucinex DM, I took one tablet around 10pm fell asleep at midnight woke up at 2am jittery still completely wide awake at 6am, good news is I can breathe clearly I haven't coughed in 8 hours; it works that's why I give it a 9, but this stuff is really powerful, I might be awake another 24 hours."

9 / 10

Was this helpful?Yes No

46 Report

Are you taking this medicine?

Solo
February 18, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "It's 2:30 am and I'm wide awake! At the suggestion of my doctor, she said to take Mucinex D ... BIG MISTAKE! I'm definitely breathing perfectly, but I'm jittery and unable to sleep! Mucinex D in the morning, Sinex at night!"

7 / 10

Was this helpful?Yes No

47 Report

Lacie
Taken for less than 1 month
September 16, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I took two pills at 3:00 pm, I fell asleep around 10:30 pm and woke up wide awake at 1:00 am! I'm still sneezing and coughing but I'm feeling better than I was before so it works but now I'm wide awake and can fall back asleep and I feel funny like my heart beat is slower. I sure hope this feeling passes!"

8 / 10

Was this helpful?Yes No

44 Report

Clare...
August 24, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Can't help but laugh reading everyone's responses here.. Yes I guess the mucinex helped my congestion maybe 20% more than if I hadn't taken it... BUT I'm wide awake as my mind is racing like I'm on crack .. Paranoid.. Can't sleep a wink. Never done crack but if I had to guess side effects would be similar.. Bummer . Just another confirmation that all natural and a few days longer is better than watching the sun come up while random paranoia thoughts race through the brain. Wish I read the fine print before I starting dosing"

2 / 10

Was this helpful?Yes No

36 Report

ArielL
November 17, 2013

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "This medicine works great. I took two pills every twelve hours and my congestion and pressure was gone within two days. HOWEVER, DO NOT TAKE THIS AT NIGHT. I am talking little to no sleep...tossing and turning, waking up every 30 minutes, etc. So just take two pills in the morning and it will be all good!"

Was this helpful?Yes No

44 Report

Jmich...
Taken for less than 1 month
February 9, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I've been plugged up literally for years and had found no relief until now. I had tried everything from frequently rinsing my sinuses with a neti pot system, to prescriptions such as Nasonex, warm/moist heating pads, other over the counter medicines, etc. At this moment I feel pretty great. I took my first Mucinex D tab yesterday late afternoon and my second one this morning. My nose feels completely clear, the pressure behind my eyes is gone, my head feels normal for once....even my ears feel less plugged and are not clicking and popping nearly as much as usual. I'm surprised I have not had the insomnia and jitters that it seems most others have experienced. No unpleasant side effects so far. I highly recommend this! The relief is worth the $$."

9 / 10

Was this helpful?Yes No

41 Report

aolani
Taken for 5 to 10 years
April 22, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Whenever I use the 12-hour tabs, it helps almost immediately in satiating my urge to cough and/or does a good job of loosening whatever junk is in my chest. Grateful for that. However, it is now 1:46am -- been eyes-wide awake since 12midnight. I took 1 pill around 3pm, fell asleep nicely by 9pm, but BOOM - now jittery and think I'm going crazy, wondering why I can't fall back asleep. Praying. I will not take this anymore, or will only try to take an a.m. dose & skip the p.m. dose. Glad the mucus is lessening, but so not glad about missing sleep."

8 / 10

Was this helpful?Yes No

33 Report

Anonymous
May 24, 2010

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Took one pill before bed (about 8 pm) and was up, literally all night. Fell asleep the next morning at 9 am. The pill worked great on my sinuses but should have taken it in the morning. The packaging does not detail this side effect very well."

8 / 10

Was this helpful?Yes No

45 Report

Sinus...
Taken for less than 1 month
April 14, 2013

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I have suffered from allergic rhinitis all my life: dry swollen sinus; sinus pressure; headaches; blurry vision; dizziness; lethargy; all sorts of cognitive problems because of the lack of oxygen to my body and brain due to thicken mucus in my respiratory system; not to mention frequent bacterial infections due to accumulated mucus secretions. I had tried every other medicine under the sun. Mucinex has taken all that away and my quality of life has improved 150%. I strongly recommend Mucinex for those with sinus problems due to allergic rhinitis, or anyone who suffers from sinus any sort of respiratory congestion period."

10 / 10

Was this helpful?Yes No

37 Report

Kmac
February 29, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I took mucinex d before bed because by sinuses were congested and I could feel mucus in my lungs making it hard to breathe. Shortly after taking the medication everything loosened up, my nose ran but I could breathe. Unfortunately it's now 6am and I haven't slept a wink and have had a rapid heart rate and anxiety. I have a headache and am too jittery to sleep. I did feel slight nauseous after I took the pill and very dry mouth now."

4 / 10

Was this helpful?Yes No

27 Report

Mandy
Taken for less than 1 month
April 6, 2019

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Calmed that annoying every 30 second cough buttttttt I barely slept a wink! I'm really happy to have relief from the cough so I can't complain to much. No jitters or anxiety - but I'm up at 5 am googling 'does mucinex DM keep u awake" lol it does absolutely keep you up it is the pseudoephedrine ingredient . I wouldn’t recommend the nightly dosage if you want to to sleep at all just in the morning. Had a quite a few hot flashes as well. Kept wanting to turn the airconditioner down lower than ever?"

8 / 10

Was this helpful?Yes No

18 Report

Galatea
Taken for less than 1 month
May 9, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I'm having a very severe nasal congestion from a cold. My normal DayQuil/NyQuil were not helping at all. Tried Sudafed, also did not help. Went to chemist in search of powerful medication and got the highest dosage of Mucinex D at the pharmacist's recommendation. Was warned about possible insomnia so I took 1 pill at 5pm thinking it's still more than 5 hours to bed time and I should be fine. Well, the congestion was gone. But I was up for the next 28 hours straight. The congestion returned after about 15 hours which makes me think the medicines effect must have worn off and I can take a nap. But no. After being up for 28 hours I decided that if I'm not getting any rest I may never get over my cold so I took a sleeping pill."

3 / 10

Was this helpful?Yes No

30 Report

jodio...
January 21, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I took this medicine (2 pills) at 9 PM. I went up to bed at 10:30 and was not able to sleep all night. I tossed and turned, felt wide awake, and I am now at work. It did clear my sinuses and my severe headache is gone. It also made me feel jittery or like I am experiencing anxiety. I am definitely only going to take this first thing in the morning."

Was this helpful?Yes No

30 Report

k8fea...
Taken for less than 1 month
October 10, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Started taking this a week ago because of terrible congestion in my head and chest along with RX Tessalon Perles. I'd taken something years before with the same ingredients as Mucinex that helped immensely and thought that the money was worth it. I've been on it a week, every twelve hours, and haven't been able to sleep more than five hours a night (about 4am after taking it at midnight until 9 am.) I still have terrible congestion with heavy thick mucus. Just finally realized about thirty minutes ago that the Mucinex is the only change. I can't rest AND with the added jitters and insomnia I feel worse than before. I wish I hadn't taken it to begin with."

1 / 10

Was this helpful?Yes No

26 Report

Ceece...
December 11, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I was diagnosed with chronic bronchitis and/or COPD. When I get a cold it usually goes straight to my chest and I end up coughing for days, Liquid Mucinex is the only thing that kept the cold out of my chest! "

9 / 10

Was this helpful?Yes No

28 Report

No...
Taken for less than 1 month
April 17, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I was getting really sick but had to travel for work. My lungs hurt so badly I thought I was going to land myself in the ER. I got off a flight and grabbed some Mucinex at the airport and got to my hotel. I was having such a hard time breathing and was coughing so badly I hadn't slept in nights. I took the mucinex and slept all night long and woke up and got stuff out of my lungs and felt SO much better."

10 / 10

Was this helpful?Yes No

26 Report

kfrye
September 17, 2013

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I have to say, I wish I read this blog beforehand. I took a Mucinex D at 7pm last night and it's 9:30 am, I haven't really gone to sleep. I tried to fall asleep around 11pm, and after 2 1/2 hours of tossing and turning and CRAZY dreams where I wasn't really asleep but wasn't completely awake either, I got up and watched some T.V to get my mind to settle down. Needless to say, I was never tired after that so I've been up since. I noticed several people saying that you should only take one pill. The back of my box says to take 2 pills every 12 hours so I'm assuming there are two different types. Just beware....not only did it give me insomnia, but the dreams were seriously weird."

8 / 10

Was this helpful?Yes No

29 Report

Tired...
January 10, 2014

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I have not slept in 2 nights. It's 4 am and I'm wide awake. I'm so glad I found this website because I thought there might me something wrong with me. Would have never thought Mucinex was the culprit! Although it has definitely cleared up all my congestion. "

5 / 10

Was this helpful?Yes No

27 Report

Mich
November 21, 2008

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Twice this year I have had a cold and used this product. Both times, I took the two pills. It cleared my head, but it left me feeling restless, and I suffered from insomnia. I will try 1 pill the next time to see how I react. Maybe 2 pills is too much medicine for me."

8 / 10

Was this helpful?Yes No

37 Report

JustW...
December 16, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Avoid. I feel like I am on speed. In fact, I told this to my husband the night before, when I couldn't sleep. 9am, & I am on currently on night 3 of sleeplessness, as I only now thought to look up side effects. I am livid. Who on Earth would want to be unable to sleep when sick?!? I'm mad my husband didn't buy the medicine I requested! He actually told the pharmacist my symptoms, and this is what was recommended. It hasn't done ANYTHING except kept me awake for 3 days. I've been congested with terrible sinus headaches. This medication hasn't touched it... As a result, I still have this sinus congestion with terrible pressure headaches, only now I also feel extremely anxious, ALERT, and my eyeballs feel as though they're going to shrivel up."

1 / 10

Was this helpful?Yes No

21 Report

Vanessa...
Taken for less than 1 month
July 24, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Definitely helped relieve my sinus pressure and loosen up mucous. I did feel nauseous after taking mucinex D. It's 2:18am and I'm still up so I decided to google insomnia and mucinex D.. And here I am. At least my congestion improved."

7 / 10

Was this helpful?Yes No

22 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.