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Diabetes Insipidus


Diabetes insipidus (DI) is a disease that causes frequent urination. The amount of urine you make is controlled by antidiuretic hormone (ADH). ADH is made in a part of the brain called the hypothalamus. ADH is stored and released by the pituitary gland. The 2 most common types of diabetes insipidus are central DI (CDI) and nephrogenic DI (NDI).



  • Medicines may be given to decrease the amount you urinate.
  • Take your medicine as directed. Contact your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Follow up with your healthcare provider as directed:

You may need to return for more blood and urine tests to check if your treatments are working. Write down your questions so you remember to ask them during your visits.

Weigh yourself each day:

Weigh yourself daily at the same time, on the same scale. Rapid weight loss can be a sign of fluid loss in your body.

Drink liquids as directed:

Ask your healthcare provider how much liquid to drink each day and which liquids are best for you.


You may need to decrease the amount of sodium (salt) you eat if you have NDI. This may help decrease the amount of fluids you lose. Ask for more information about the meal plan you should follow.

Contact your healthcare provider if:

  • You have a dry mouth or cracked lips.
  • You are more tired than usual.
  • You have new headaches or vision changes.
  • You have questions or concerns about your condition or care.

Return to the emergency department if:

  • You feel very thirsty all the time, and your thirst is waking you from sleep.
  • You are urinating large amounts of light yellow, or clear urine.
  • You are losing weight daily without trying.
  • You feel weak and dizzy, or have fainted.
  • You feel confused.
  • You have a seizure.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Learn more about Diabetes Insipidus (Aftercare Instructions)

Associated drugs

Micromedex® Care Notes

Mayo Clinic Reference