Generic Name: Sodium Oxybate (SOW dee um ox i BATE)
Brand Name: Xyrem
Medically reviewed on Sep 5, 2018
- This medicine may slow down your breathing too much. Talk with your doctor.
- Abuse and misuse of Xyrem (sodium oxybate) by itself or with certain other drugs may cause seizures, slow or shallow breathing, changes in alertness, coma, or death. Talk with the doctor.
- You may only get Xyrem (sodium oxybate) through a special program. Talk with your doctor.
Uses of Xyrem:
- It is used to treat sudden loss of muscle tone (cataplexy) in patients with narcolepsy.
- It is used to treat a lot of sleepiness during the day in patients with narcolepsy.
What do I need to tell my doctor BEFORE I take Xyrem?
- If you have an allergy to sodium oxybate or any other part of Xyrem (sodium oxybate).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have succinic semialdehyde dehydrogenase deficiency.
- If you drink alcohol or take any drugs that have alcohol.
- If you are taking any drugs or natural products used for sleep. There are many products used for sleep. Ask your doctor or pharmacist if you are not sure.
This is not a list of all drugs or health problems that interact with Xyrem (sodium oxybate).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Xyrem (sodium oxybate) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Xyrem?
- Tell all of your health care providers that you take Xyrem (sodium oxybate). This includes your doctors, nurses, pharmacists, and dentists.
- If you have been taking Xyrem (sodium oxybate) on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking Xyrem (sodium oxybate) all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.
- Avoid driving and doing other tasks or actions that call for you to be alert for at least 6 hours after taking Xyrem (sodium oxybate). Avoid these tasks or actions until you feel fully awake.
- Avoid drinking alcohol while taking Xyrem (sodium oxybate).
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- Many drugs interact with Xyrem (sodium oxybate) and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use Xyrem (sodium oxybate) with all of your drugs.
- After taking Xyrem (sodium oxybate), it is likely you will fall asleep very fast (most of the time within 5 to 15 minutes). The time that it takes to fall asleep can change from night to night. Falling asleep all of a sudden when standing or rising from bed has led to falls and the need to go to the hospital. Be sure you take Xyrem (sodium oxybate) while in bed and lie down right away after taking it. Talk with your doctor.
- If you are on a low-sodium or sodium-free diet, talk with your doctor. Some of these products have sodium.
- If you are 65 or older, use Xyrem (sodium oxybate) with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Xyrem (sodium oxybate) while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Xyrem) best taken?
Use Xyrem (sodium oxybate) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take on an empty stomach. Take at least 2 hours after eating.
- Keep the time the same between the last food of the day and the first dose.
- Take 2 doses each night.
- Take at the same time every night.
- This medicine needs to be mixed before use. Follow how to mix as you were told by the doctor.
- Prepare each dose before going to bed.
- Use within 24 hours after you mix Xyrem (sodium oxybate).
- Place in child-resistant dosing cups on bedside table.
- Take first dose at bedtime after getting into bed.
- Stay in bed after taking doses.
- Space doses by at least 2.5 to 4 hours.
- Set alarm clock to wake up for second dose.
What do I do if I miss a dose?
- If you miss the second dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
- Hallucinations (seeing or hearing things that are not there).
- Feeling confused.
- Change in the way you act.
- Trouble breathing, slow breathing, or shallow breathing.
What are some other side effects of Xyrem?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Upset stomach or throwing up.
- Loose stools (diarrhea).
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Xyrem?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Xyrem (sodium oxybate) is refilled. If you have any questions about Xyrem (sodium oxybate), please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Xyrem (sodium oxybate)
- Xyrem Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 77 Reviews
- Generic Availability
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics
- FDA Alerts (1)