Skip to Content
How to talk to a doctor about advanced ovarian cancer >>

Totect

Generic Name: dexrazoxane (DEX-ra-ZOX-ane)
Brand Name: Examples include Totect and Zinecard

Totect is used for:

Reducing the risk and severity of heart problems associated with the chemotherapy medicine doxorubicin in certain women being treated for metastatic breast cancer. It is also used to treat tissue damage caused by certain cancer medicines that leak from the vein into the skin around the injection site.

Totect is a cytoprotective and cardioprotective agent. Exactly how Totect works is not known.

Do NOT use Totect if:

  • you are allergic to any ingredient in Totect
  • one of your other chemotherapy treatments is not an anthracycline (eg, doxorubicin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Totect:

Some medical conditions may interact with Totect. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow problems (eg, low blood platelet levels, low red blood cell levels, low white blood cell levels), or kidney or liver problems

Some MEDICINES MAY INTERACT with Totect. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if Totect may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Totect:

Use Totect as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet may be available with Totect. Talk to your pharmacist if you have questions about this information.
  • Totect is usually given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Do not use Totect if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If Totect comes into contact with the skin, wash it off right away with soap and water.
  • If you miss a dose of Totect, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use Totect.

Important safety information:

  • Chemotherapy medicines may reduce the number of clot-forming cells (platelets) in your blood. Totect may add to this effect. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Chemotherapy medicines may lower the ability of your body to fight infection. Totect may add to this effect. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • The use of Totect along with certain other chemotherapy medicines may increase the risk of developing a second cancer. Discuss any questions or concerns with your doctor.
  • Women who may become pregnant must use an effective form of birth control while taking Totect. If you have questions about effective birth control, talk with your doctor.
  • Lab tests, including heart function and complete blood cell counts, may be performed while you use Totect. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Totect is not approved for use in CHILDREN. An increased risk of developing a second cancer has been reported in children taking some brands of Totect along with cancer medicines. Discuss any questions with your doctor.
  • PREGNANCY and BREAST-FEEDING: Totect may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Totect while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Totect.

Possible side effects of Totect:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; loss of appetite; mild pain at the injection site; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; pain, redness, or swelling at the injection site; swelling or soreness of the mouth or tongue; symptoms of infection (eg, fever; chills; persistent sore throat or cough; increased, difficult, or painful urination; warm, red, or swollen skin) signs of bleeding (eg, throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop); unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Totect:

Totect is handled and stored by a health care provider. Keep Totect out of the reach of children and away from pets.

General information:

  • If you have any questions about Totect, please talk with your doctor, pharmacist, or other health care provider.
  • Totect is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Totect or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Totect. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Totect. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Totect.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide