Generic Name: Dexrazoxane (deks ray ZOKS ane)
Brand Name: Totect, Zinecard
Medically reviewed by Drugs.com. Last updated on Oct 30, 2020.
Uses of Totect:
- It is used to lower the side effects of doxorubicin.
- It is used to treat tissue damage caused by some drugs if they leak from the vein while they are being given.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Totect?
- If you are allergic to Totect (dexrazoxane); any part of Totect (dexrazoxane); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are using a drug on the skin called dimethyl sulfoxide (DMSO).
- If you have liver disease.
- If you are breast-feeding. Do not breast-feed while you take Totect (dexrazoxane). You may also need to avoid breast-feeding for some time after your last dose. Talk with your doctor to see if you need to avoid breast-feeding after your last dose.
This is not a list of all drugs or health problems that interact with Totect (dexrazoxane).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Totect (dexrazoxane) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Totect?
- Tell all of your health care providers that you take Totect (dexrazoxane). This includes your doctors, nurses, pharmacists, and dentists.
- Allergic reactions have happened with Totect (dexrazoxane). Rarely, some reactions can be very bad or life-threatening. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You will need to have heart function tests while taking Totect (dexrazoxane). Talk with the doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Other cancers have happened when Totect (dexrazoxane) was used with cancer drugs. Talk with the doctor.
- If you are 65 or older, use Totect (dexrazoxane) with care. You could have more side effects.
- This medicine may affect being able to father a child. Talk with the doctor.
- If you are a man and have sex with a female who could get pregnant, you may need to protect her from pregnancy during treatment and for some time after your last dose. Talk with your doctor to see if you need to use birth control after your last dose.
- If you are a man and your sex partner gets pregnant while you take Totect (dexrazoxane) or within several months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- You may need to have a pregnancy test while taking Totect (dexrazoxane). Talk with your doctor.
- Use birth control to prevent pregnancy during treatment with Totect (dexrazoxane). You may also need to use birth control for some time after your last dose. Talk with your doctor to see if you need to use birth control after you stop Totect (dexrazoxane).
- If you get pregnant while taking Totect (dexrazoxane) or within several months after the last dose, call your doctor right away.
How is this medicine (Totect) best taken?
Use Totect (dexrazoxane) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
- Dizziness or passing out.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- A burning, numbness, or tingling feeling that is not normal.
- Low mood (depression).
What are some other side effects of Totect?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
- Hair loss.
- Irritation where the shot is given.
- Pain where the shot was given.
- Feeling tired or weak.
- Trouble sleeping.
- Mouth irritation or mouth sores.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Totect?
- If you need to store Totect (dexrazoxane) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Totect (dexrazoxane), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Totect (dexrazoxane)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: miscellaneous uncategorized agents
- FDA Approval History
Other brands: Zinecard