Skip to Content

Totect Side Effects

Generic Name: dexrazoxane

Note: This document contains side effect information about dexrazoxane. Some of the dosage forms listed on this page may not apply to the brand name Totect.

For the Consumer

Applies to dexrazoxane: intravenous powder for solution

Along with its needed effects, dexrazoxane (the active ingredient contained in Totect) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dexrazoxane:

More common
  • Bluish color
  • changes in skin color
  • chest pain
  • chills
  • cold hands and feet
  • cough
  • difficult or labored breathing
  • fever
  • hoarseness
  • lower back or side pain
  • pain, redness, or swelling in the arm or leg
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • swelling of the hands, ankles, feet, or lower legs
  • tenderness
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Black, tarry stools
  • chest discomfort
  • fast, irregular, or pounding heartbeat
  • pain at the injection site
  • ulcers, sores, or white spots in the mouth

Some side effects of dexrazoxane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • difficulty having a bowel movement
  • discouragement
  • dizziness
  • feeling sad or empty
  • hair loss
  • headache
  • irritability
  • lack or loss of appetite
  • loss of interest or pleasure
  • muscle pain, spasms, cramps, or stiffness
  • nausea
  • stomach pain
  • thinning of the hair
  • trouble concentrating
  • trouble sleeping
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to dexrazoxane: intravenous powder for injection


General side effects including pyrexia (21%), postoperative infection (16%), fatigue (13%), peripheral edema (10%), chest pain, chest discomfort, decreased drug effect, hyperpyrexia, and decreased therapeutic response have been reported.[Ref]


Gastrointestinal side effects including nausea (43%), vomiting (19%), diarrhea (11%), abdominal pain (6%), and constipation (6%) have been reported.[Ref]


Hematologic side effects including anemia (6%), decreased WBC, decreased neutrophils, and decreased platelets have been reported.[Ref]


Dermatologic side effects including alopecia (14%) have been reported.[Ref]


Local side effects including injection site pain (16%) and injection site phlebitis (6%) have been reported.[Ref]

Nervous system

Nervous system side effects including dizziness (11%) and headache (6%) have been reported.[Ref]


Hepatic side effects including increased bilirubin, increased AST, increased ALT, increased alkaline phosphatase, and increased LDH have been reported[Ref]


Metabolic side effects including increased creatinine, decreased sodium, and increased total calcium have been reported.[Ref]


Cardiovascular side effects including vascular disorders (15%) and cardiac disorders (5%) have been reported.[Ref]


Psychiatric side effects including depression (8%), anorexia (5%), and insomnia (5%) have been reported.[Ref]


Respiratory side effects including dyspnea (8%), pneumonia (6%), and cough (5%) have been reported.[Ref]


1. "Product Information. Totect (dexrazoxane)." Cumberland Pharmaceuticals Inc, Nashville, TN.

Some side effects of Totect may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.