Generic Name: Procarbazine (proe KAR ba zeen)
Brand Name: Matulane
Medically reviewed on Sep 5, 2018
Uses of Procarbazine:
- It is used to treat a type of lymphoma.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Procarbazine?
- If you have an allergy to procarbazine or any other part of procarbazine.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Low white blood cell count, low platelet count, or very bad anemia.
- If you have recently had radiation or other chemo.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with procarbazine, like certain drugs that are used for coughs and colds, low mood (depression), or weight loss. There are many drugs that must not be taken with procarbazine.
- If you are breast-feeding. Do not breast-feed while you take procarbazine.
This is not a list of all drugs or health problems that interact with procarbazine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take procarbazine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Procarbazine?
- Tell all of your health care providers that you take procarbazine. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how procarbazine affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Other cancers have happened when procarbazine was used with cancer drugs. Talk with the doctor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use with procarbazine may either raise the chance of an infection or make the vaccine not work as well.
- Avoid drinking alcohol while taking procarbazine.
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- Do not smoke, chew tobacco, or use other products that have nicotine while you are using procarbazine.
- Some foods and drinks like cheese and red wine, when taken with procarbazine, may cause very risky effects such as sudden high blood pressure. To avoid these problems, get a list of foods to avoid.
- If procarbazine is stopped, follow diet for at least 2 more weeks.
- Use with care in children. Talk with the doctor.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking procarbazine.
- If you are pregnant or you get pregnant while taking procarbazine, call your doctor right away.
How is this medicine (Procarbazine) best taken?
Use procarbazine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with a full glass of water.
- Take with or without food.
- How procarbazine is taken may change based on blood work results, side effects, and how well the drug is working.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
For all patients taking procarbazine:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Shortness of breath.
- Very bad dizziness or passing out.
- A fast heartbeat.
- Loose stools (diarrhea).
- A burning, numbness, or tingling feeling that is not normal.
- Feeling confused.
- Change in eyesight, eye pain, or very bad eye irritation.
- If bright lights bother your eyes.
- Hearing loss.
- Change in balance.
- Feeling very tired or weak.
- Mouth irritation or mouth sores.
- Trouble swallowing.
- Not able to control eye movements.
- Mood changes.
- Hallucinations (seeing or hearing things that are not there).
- Bad dreams.
- Passing urine more often.
- Sweating a lot.
- Slurred speech.
- For males, enlarged breasts.
What are some other side effects of Procarbazine?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Not hungry.
- Upset stomach or throwing up.
- Dry mouth.
- Hair loss.
- Belly pain.
- Hard stools (constipation).
- Muscle or joint pain.
- Feeling tired or weak.
- Not able to sleep.
- Change in color of skin.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Procarbazine?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about procarbazine, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about procarbazine
- Procarbazine Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: miscellaneous antineoplastics
Other brands: Matulane