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Lynparza (Olaparib)

Generic Name: Olaparib (oh LAP a rib)
Brand Name: Lynparza

Uses of Lynparza:

  • It is used to treat ovarian cancer.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Lynparza?

  • If you have an allergy to Lynparza (olaparib) or any part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had chemo treatments before and you still have blood problems from those treatments.
  • If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with Lynparza, like certain drugs that are used for HIV, infections, or seizures.
  • If you are taking St. John's wort. Do not take St. John's wort with this medicine. This medicine may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take Lynparza or for 1 month after you stop this medicine.

This is not a list of all drugs or health problems that interact with Lynparza.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Lynparza?

  • Tell all of your health care providers that you take Lynparza. This includes your doctors, nurses, pharmacists, and dentists.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Do not switch between different forms of this medicine without first talking with the doctor.
  • If you are 65 or older, use Lynparza with care. You could have more side effects.
  • This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting this medicine. Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking Lynparza and for 6 months after stopping this medicine.
  • If you get pregnant while taking Lynparza (olaparib) or within 6 months after your last dose, call your doctor right away.

How is this medicine (Lynparza) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Take with or without food.
  • Swallow whole. Do not chew, break, or melt.
  • Avoid Seville oranges.
  • Avoid grapefruit and grapefruit juice.
  • To gain the most benefit, do not miss doses.
  • Keep taking Lynparza as you have been told by your doctor or other health care provider, even if you feel well.

Capsules:

  • Do not open the capsules.
  • Do not take the capsule if it is deformed or leaking.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
  • Swelling in the arms or legs.
  • Very bad and sometimes deadly lung problems have happened with this medicine. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Some people have had certain bone marrow problems while taking Lynparza. This includes a type of cancer called acute myeloid leukemia (AML). These problems may be deadly. These people all had other treatments with chemo or certain other drugs for their cancer before taking this medicine. Call your doctor right away if you have blood in the urine or stools, fever, infections that happen often, shortness of breath, any bruising or bleeding, feel very tired or weak, or have weight loss.

What are some other side effects of Lynparza?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Back pain.
  • Hard stools (constipation).
  • Not hungry.
  • Dizziness.
  • Headache.
  • Heartburn.
  • Muscle or joint pain.
  • Nose or throat irritation.
  • Change in taste.
  • Feeling tired or weak.
  • Mouth irritation or mouth sores.
  • Signs of a common cold.
  • Flu-like signs.
  • It is common to have diarrhea, upset stomach, throwing up, or stomach pain with Lynparza. Call your doctor if any of these side effects get very bad, bother you, or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Lynparza?

All products:

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Capsules:

  • Avoid temperatures higher than 104 degrees F (40 degrees C). Do not take this medicine if it has been at a temperature higher than 104 degrees F (40 degrees C).

Tablets:

  • Store in original container.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Lynparza is refilled. If you have any questions about this medicine, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Lynparza or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lynparza. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: September 6, 2017

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