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Invirase capsules

Generic Name: saquinavir (sa-KWIN-a-vir)
Brand Name: Invirase

Invirase capsules are used for:

Treating HIV infection. Invirase capsules must be taken along with ritonavir.

Invirase capsules are a protease inhibitor. It works by blocking the growth of HIV.

Do NOT use Invirase capsules if:

  • you are allergic to any ingredient in Invirase capsules or to ritonavir
  • you have severe liver problems, certain electrolyte problems (eg, low blood potassium or magnesium levels), or a certain type of irregular heartbeat (heart block) and you do not have a pacemaker, or if you are at risk of heart block
  • you have a history of a certain type of irregular heartbeat (eg, congenital long QT syndrome, QT prolongation)
  • you are taking alfuzosin, amiodarone, bepridil, cisapride, dihydroergotamine, dofetilide, ergonovine, ergotamine, flecainide, fusidic acid, a garlic supplement, lidocaine, lovastatin, methylergonovine, oral midazolam, pimozide, propafenone, quinidine, rifampin, salmeterol, simvastatin, tipranavir/ritonavir, trazodone, or triazolam
  • you are taking sildenafil for pulmonary arterial hypertension (PAH)
  • you take colchicine and also have kidney or liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Invirase capsules:

Some medical conditions may interact with Invirase capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems (eg, slow or irregular heartbeat, congestive heart failure [CHF]), high blood cholesterol or triglycerides, hepatitis or other liver problems, kidney problems, hemophilia, or blood electrolyte problems
  • if you have diabetes or high blood sugar, or if a member of your family has diabetes
  • if you have alcoholism or a history of alcohol abuse
  • if you are lactose intolerant
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Invirase capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for abortion, allergies, anxiety, asthma or other lung or breathing problems, birth control, blood thinning, blood vessel problems, cancer, cystic fibrosis, depression or other mental or mood problems, diabetes, erectile dysfunction, gout, heartburn or reflux, high blood pressure, high cholesterol, HIV, immune system suppression, infections, inflammation, irregular heartbeat or other heart problems, migraine headaches, narcotic dependence, nausea or vomiting, overactive bladder, PAH, pain, seizures, sleep, stomach or bowel problems), multivitamin products, and herbal or dietary supplements (eg, garlic, St. John's wort) because they may interact with Invirase capsules. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Invirase capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Invirase capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Invirase capsules:

Use Invirase capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Invirase capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Invirase capsules refilled.
  • Take Invirase capsules and ritonavir within 2 hours after a full meal.
  • Ritonavir should be taken at the same time as Invirase capsules.
  • If you cannot swallow the capsule whole, you may open it and place the contents into an empty container. Add 15 mL of either sugar syrup (or sorbitol syrup for patients with diabetes) or 3 teaspoons of jam to the container. Stir with a spoon for 30 to 60 seconds. Allow the mixture to come to room temperature, then swallow the mixture. Do not store the mixture for future use.
  • Taking Invirase capsules at the same times each day will help you to remember to take it.
  • Take Invirase capsules on a regular schedule to get the most benefit from it.
  • Talk with your doctor before you eat grapefruit or drink grapefruit juice while you use Invirase capsules.
  • Continue to take Invirase capsules even if you feel well. Do not miss any doses.
  • If you miss a dose of Invirase capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Invirase capsules.

Important safety information:

  • Tell your doctor or dentist that you take Invirase capsules before you receive any medical or dental care, emergency care, or surgery.
  • Invirase capsules interacts with many other medicines. The risk of Invirase capsules's side effects may be increased or Invirase capsules's effectiveness may be decreased. The risk of the other medicines' side effects may also be increased. This may include severe, life-threatening, or fatal side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take Invirase capsules with all of your other medicines (prescription or over-the-counter, natural products, vitamins).
  • Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk; loss of fat from the legs, arms, and face) may occur in some patients taking Invirase capsules. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
  • Invirase capsules may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Invirase capsules.
  • Do not stop taking Invirase capsules or change your dose without talking to your doctor.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Invirase capsules, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • Invirase capsules are not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
  • Invirase capsules does not stop the spread of HIV to others through blood or sexual contact. Do not have any kind of sex without protection (eg, latex or polyurethane condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HIV to others.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Invirase capsules. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Hemophilia patients - Some people with hemophilia have developed increased bleeding while taking protease inhibitors, such as Invirase capsules. Report all bleeding episodes to your doctor.
  • Invirase capsules may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, urinate more often than usual, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Severe skin reactions (eg, Stevens-Johnson syndrome/toxic epidermal necrolysis) have happened with Invirase capsules. They can cause serious health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Lab tests, including liver function, electrocardiogram (ECG), blood cholesterol or triglyceride levels, blood glucose levels, and blood electrolyte levels, may be performed while you use Invirase capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Invirase capsules while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Invirase capsules. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Invirase capsules to the baby.

Possible side effects of Invirase capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; mild stomach pain; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; burning, numbness, or tingling; chest pain; confusion; coughing up blood; decreased coordination; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent cough or sore throat; flu-like symptoms; mental or mood changes (eg, depression); one-sided weakness; seizures; severe or persistent headache; shortness of breath; slurred speech; stomach pain or tenderness; suicidal thoughts or attempts; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, right-sided stomach pain, yellowing of the skin or eyes); unusual bruising or bleeding; unusual tiredness or weakness; vision changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Invirase capsules:

Store Invirase capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed bottle. Store away from heat, moisture, and light. Do not store Invirase capsules in the bathroom. Keep Invirase capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about Invirase capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Invirase capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Invirase capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Invirase capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Invirase capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Invirase capsules.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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