Generic Name: Docetaxel Injection (doe se TAKS el)
Brand Name: Docefrez, Taxotere
Medically reviewed by Drugs.com. Last updated on Sep 28, 2019.
- Very bad and sometimes deadly allergic reactions have happened with Docefrez (docetaxel injection). Do not take Docefrez (docetaxel injection) if you have ever had an allergic reaction to Docefrez (docetaxel injection) or to other drugs that have polysorbate 80 in them.
- The risk of death that may rarely happen with Docefrez (docetaxel injection) is raised in people with liver problems and in people who get high doses of this drug. The risk is also raised in people with a certain type of lung cancer who have been treated with a platinum-based chemo drug in the past. This medicine must not be given to some people with high bilirubin levels, liver problems, or raised liver enzymes. If you have any of these health problems or any questions, talk with your doctor.
- This medicine may cause you to swell or keep fluid in your body. Tell your doctor if you have swelling, weight gain, or trouble breathing.
- This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If you have a low white blood cell count, talk with your doctor. This medicine must not be used in people with certain low white blood cell counts.
The Docefrez brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Uses of Docefrez:
- It is used to treat cancer.
What do I need to tell my doctor BEFORE I take Docefrez?
- If you have an allergy to docetaxel or any other part of Docefrez (docetaxel injection).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are taking any of these drugs: Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, or telithromycin.
- If you are taking voriconazole.
- If you are breast-feeding. Do not breast-feed while you take Docefrez (docetaxel injection) and for 1 week after your last dose.
This is not a list of all drugs or health problems that interact with Docefrez (docetaxel injection).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Docefrez (docetaxel injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Docefrez?
- Tell all of your health care providers that you take Docefrez (docetaxel injection). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Docefrez (docetaxel injection) affects you.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Talk with your doctor before getting any vaccines. Use of some vaccines with Docefrez (docetaxel injection) may either raise the chance of an infection or make the vaccine not work as well.
- Rarely, other cancers have happened in people taking Docefrez (docetaxel injection) with some other cancer treatments. This includes certain blood cancers and kidney cancer. This may happen months to years after treatment. If you have questions, talk with the doctor.
- Hair loss is common with Docefrez (docetaxel injection). Most of the time, normal hair growth has come back. Sometimes, hair growth has not gone back to normal. Talk with the doctor.
- Some people have felt very tired or weak with Docefrez (docetaxel injection). This may last a few days up to several weeks. Call the doctor if these signs are very bad, cause problems with daily living, or do not go away.
- This medicine can cause a severe bowel problem (neutropenic enterocolitis). This problem can be deadly, sometimes as early as the first day signs happen. Call your doctor right away if you have stomach pain with or without a fever, tender stomach, or diarrhea.
- Liver problems have rarely happened with Docefrez (docetaxel injection). Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- If you are 65 or older, use Docefrez (docetaxel injection) with care. You could have more side effects.
- This medicine may affect being able to father a child. Talk with the doctor.
- Men with a partner who may get pregnant must use birth control while taking Docefrez (docetaxel injection) and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.
- This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start Docefrez (docetaxel injection) to show that you are NOT pregnant.
- Women must use birth control while taking Docefrez (docetaxel injection) and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
- This medicine has alcohol in it. This may cause you to feel drunk during and after treatment. Tell your doctor if you have confusion, feel drunk, stumble, or feel very sleepy during treatment or within 1 to 2 hours after treatment.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
How is this medicine (Docefrez) best taken?
Use Docefrez (docetaxel injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- A steroid drug like dexamethasone will be given before Docefrez (docetaxel injection) to lower side effects. Talk with the doctor. Tell the doctor if the steroid drug is not used as your doctor has told you.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of lung or breathing problems like shortness of breath or other trouble breathing, cough, or fever.
- Dizziness or passing out.
- Fast or abnormal heartbeat.
- A burning, numbness, or tingling feeling that is not normal.
- Muscle weakness.
- Any skin reaction.
- This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
- This medicine may cause a certain eye problem called cystoid macular edema (CME). You may need to have eye exams while using Docefrez (docetaxel injection). Call your doctor right away if you have a change in eyesight like blurred eyesight or loss of eyesight.
What are some other side effects of Docefrez?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Mouth sores.
- Feeling tired or weak.
- Change in nails.
- Change in taste.
- Not hungry.
- Muscle or joint pain.
- Eye redness.
- More tears.
- Weight loss.
- Constipation, diarrhea, throwing up, and upset stomach are common with Docefrez (docetaxel injection). If these happen, talk with your doctor about ways to lower these side effects. Call your doctor right away if any of these effects bother you, do not go away, or get very bad.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Docefrez?
- If you need to store Docefrez (docetaxel injection) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Docefrez (docetaxel injection), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Docefrez (docetaxel)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Drug class: mitotic inhibitors
- FDA Alerts (1)
- FDA Approval History
Other brands: Taxotere