Generic Name: Cobicistat (koe BIK i stat)
Brand Name: Tybost
Medically reviewed on September 5, 2018
Uses of Cobicistat:
- It is used to help the action of some other drugs used to treat HIV (atazanavir or darunavir).
- This medicine is used with atazanavir or darunavir. Talk with the doctor about the risks and side effects that may happen with those drugs.
What do I need to tell my doctor BEFORE I take Cobicistat?
- If you have an allergy to cobicistat or any part of cobicistat.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are taking another drug that has the same drug in it.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with cobicistat, like certain drugs that are used for high cholesterol, HIV, or seizures. There are many drugs that must not be taken with cobicistat.
- If you have kidney problems and are taking tenofovir.
- If you have kidney or liver disease and are taking colchicine.
This is not a list of all drugs or health problems that interact with cobicistat.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take cobicistat with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Cobicistat?
- Tell all of your health care providers that you take cobicistat. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine interacts with many other drugs. The chance of cobicistat's side effects may be raised or how well cobicistat works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take cobicistat with all of your other drugs (prescription or OTC, natural products, vitamins).
- This medicine is not a cure for HIV. Stay under the care of your doctor.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
- Do not run out of cobicistat.
- Very bad kidney problems like kidney failure have happened in people taking cobicistat with tenofovir. Talk with your doctor.
- Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking cobicistat.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using cobicistat while you are pregnant.
- Do not breast-feed if you have HIV disease unless your doctor tells you to.
How is this medicine (Cobicistat) best taken?
Use cobicistat as ordered by your doctor. Read all information given to you. Follow all instructions closely.
For all patients taking cobicistat:
- Take cobicistat with food.
- Take cobicistat at the same time as the other HIV drug you take it with (atazanavir or darunavir).
- Keep taking cobicistat as you have been told by your doctor or other health care provider, even if you feel well.
- It is important that you do not miss or skip a dose of cobicistat during treatment.
When taking cobicistat with atazanavir:
- Do not take antacids within 2 hours before or 2 hours after taking cobicistat.
- If you take cimetidine, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, pantoprazole, rabeprazole, or ranitidine, ask your doctor or pharmacist how to take it with cobicistat.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Yellow skin or eyes.
What are some other side effects of Cobicistat?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Cobicistat?
- Store in the original container at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about cobicistat, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about cobicistat
- Cobicistat Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: antiviral boosters
Other brands: Tybost