Zytiga - Is Zytiga & prednisone effective when taken by themselves?

The Use of Zytiga After Lupron to Control Prostate Cancer

Zytiga is given in combination with Lupron if Lupron was not adequately effective. Zytiga is not used alone.

Zytiga (abiraterone acetate) is based on the discovery that resistance to Lupron (defined as cancer growth despite zero testosterone in the blood) is not a result of the cancer cells having learned to grow without testosterone. Rather, Lupron resistance is a result of prostate cancer cells having learned how to manufacture their own testosterone internally.

The anticancer effect of Zytiga works by blocking an essential enzyme located inside the cancer cell, an enzyme that is an integral component in the synthetic pathway of testosterone.
Zytiga. Package insert. Janssen Biotech, Inc; 2011.

The net result is that the cancer cell is blocked from manufacturing its own testosterone.

Source: verywellhealth
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