I just recently went up on my zoloft to 100mg 6 days ago from 75mg. 7 days before that I was on 50mg for about 6 weeks. I still don't feel better at all and I'm getting very impatient. How long is a dose increase suppose to take to come in effect. I don't know wether to wait it out or just have my doctor change the medication. Also, how do you feel when it does start working.It just feels like I'll never be happy again, it's terrible