Hi, I'm a newbie. I just wanted to share that I've been on Wellbutrin for 1 year. Wellutrin alone does not work well for my depression and it gives me anxiety, plus insomnia. My doctor added Lexapro to take with Wellbutrin and it seemed to even me out but did nothing really for the depression. After trying this combo for about 9 months, I requested a change since it wasn't helping. Now I take Zoloft with Wellbutrin and I feel great!! I think this is my magic bullet!! I am very sensitive to drugs so I only take 50mg of Wellbutrin and 25 mg of Zoloft (both generic). I take them together in the morning and no side effects so far. I have energy, my mood is great, no anxiety, and I can focus at work. So far, so good! It has only been one week with this new combo and it may be too soon to tell how it will help me in the long run, but I wanted to share my experience thus far.
Has anyone else had good success with this combination??
I like a this thread. It good to remind selves medication work good good for one but bad bad for other.
I take 100 mg Zoloft and 300 Willy but trim and have much success. Thanks doctor for make a feel nice.
I ask though if others feel a bum feel what can only be pressure diplates. On the back of my swallow hole and on my bumper gus.
Any help a good get is nice. Thank you for all good reasons.
7 Nov 2021
I use the same combination and am also very sensitive to medication. How do you take 50 mg of Wellbutrin. I can’t find it in lower doses than 150 and that’s too much for me.
24 July 2020
Hello! Yes, Wellbutrin augments Zoloft well as it targets different receptor sites in the brain than Zoloft. It can help with emotional flattening, sexual side effects from the SSRI Zoloft, and with motivation and focus. I have had good success treating patients with this combination. Be cautions in those with a seizure disorder however, as the combo can lower the seizure threshold. I am a board certified psychiatric nurse practitioner two years into practice, and I have almost 17 years of experience in the mental health field. Best of luck to you going forward!
4 May 2020
"Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve. Sertraline (Zoloft) | NAMI: National Alliance on Mental Illness" "How Long Does It Take For Bupropion To Work? While depressed mood, anxiety, and lack of interest in activities may need up to 4-6 weeks to improve, disturbances in sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Bupropion (Wellbutrin) | NAMI: National Alliance on Mental Illness"
4 May 2020
So happy to see your comments it offers encouragement. I’ve been on Zoloft 150mg since March and I was still struggling with anxiety and depression and zero libido. I asked my dr about combination therapy and a week ago he added Wellbutrin XL 150mg. I’m super drug sensitive and usually react opposite with everything. Praying this combination will work and fast. Its only been a week, how long did it take for you to get the benefit of both meds? Realizing everyone is different.
26 March 2020
Yes, a close friend of mine has had great success.
26 March 2020
How is it going now that it's been a bit longer? I'm considering this combo myself, w/ those exact dose amounts b/c I too am sensitive.
24 Jan 2020
Another new, newbie here!
I suffer from Borderline Personality Disorder with Major Depression, Generalized Anxiety Disorder, and Panic Disorder.
In August, 2019, I was taken off of Cymbalta and switched over to 150mg of Wellbutrin (generic) and I was okay for a month or so but all of a sudden I felt very depressed. Around November my anxiety and irritability were becoming very noticeable. By the end of December I started suffering from severe panic attacks here and there. Three weeks ago it was the worst it has been in almost 10 years. I am constantly anxious, having several panic attacks a day, and can't sleep.
I have been on so many medications in my lifetime. They started prescribing me at 14 years old and I am now 32. Nothing has seemed to work (Buspirone, Effexor, Citalopram, Valium, trazodone, Cymbalta, Seroquel, Olanzapine, and even Wellbutrin alone when I was 16... I'm missing some but we get the point). It is now at a point where I am a single parent unable to work and my illnesses have taken over my life.
Last week my doctor prescribed 25mg of Zoloft (generic brand) and after taking it for a week he wants me to increase it to 50mg. I was told o take my Wellbutrin in the morning and Zoloft before bed. I take .05mg of Clonazepam twice daily and while I get used to these medications he has prescribed me 15 0.05mg of Ativan to use as PRN's. I'm hoping this combo helps in some way because I am so desperate. I just want my life back.
I guess I'll keep you updated ad the combo does it's thing and let you know how it worked for me personally.
17 May 2019
Was given a prescription today for this combo. Took Lexapro for about a year. Stopped working. Started on Zoloft 50 a few months ago. Raised to 100 within the last month. Doctor started me today on adding 150 Wellbutrin to the existing Zoloft. Curious to see how this works and a tad nervous. Also in menopause and in need of total hysterectomy. Being a girl isn’t for the weak
10 Feb 2019
I was taking 300 mg Wellbutrin but think it makes me little shaky so we went down to 150 Wellbutrin and went up on Zoloft to 100 mg. So far I think this is a good combo for me. Glad to hear other people out there are having positive results on this cocktail. I also take Ambien 10mg for sleep. It's my magic sleeping pill. I love it. I have been on Ambien for over 15 years. I'm was starting to worry about long term side effects of taking it so long. Does anyone know about long term use of Ambien??
9 Feb 2019
Hello - I’m a newbie too... YES! It’s the magic bullet for me as well!
I had taken sertraline at 200mg for severe anxiety for several years, which worked well. But my “brain fog” - which I did not recognise as residual depression at the time - persisted. Adding bupropion has worked like magic - the brain fog disappeared in 3 days. The only thing is that I am now sleeping for 12+ hours, I’ve read that bupropion can enhance the effect of “SSRI fatigue” so I’m thinking of asking my doctor to reduce the sertraline part of the combo. Has anyone else felt sleepy on this combo?
6 Aug 2018
Hi, I just started on the generic version of Wellbutrin, Bupropion HCL XL. I have been on Zoloft for a few years with no great response so my Dr. added this. I'm taking 150mg daily of the Bupropion and 100mg Zoloft. Even though the effects usually doesn't show for about 4 weeks, I don't feel that cloud over my head. I'm hoping this works. I can't stand not being able to concentrate at work, sluggish at home, and just plain unfocused.
28 March 2018
My Dr started me out on 300 mg of Wellbutrin and buspar (which was supposed to help with my anxiety). I ended up in the ER with a severe panic attack. My Dr. adjusted my meds to 150mg of Wellbutrin and 50 mg of Zoloft. I haven't had anxiety since! So far this combo has worked for me.
28 March 2018
I have been taking this combo now for 7mos and I take 100mg of Zoloft and 200mg Wellbutrin.. generic.. originally for postpartum depression.. but it seems to work rather well for me.. I am able to function and enjoy life.. my children.. family.. and the world around me.. so far this has been my perfect combo.. and I have tried many.. I am functional again..
27 March 2018
I take 150 Wellbutrin with 100 Zoloft and the combo is working well for me too