There is a moderate drug interaction between ibuprofen and prednisone:
You shouldn’t take ibuprofen with prednisone unless your doctor has told you to do so. The two together increase the risk of a stomach or duodenal ulcer developing. Some doctors may combine a low dose of prednisone with ibuprofen or any other non-steroidal anti-inflammatory drug for a very short time but usually consider adding a proton pump inhibitor (eg. Prilosec) to reduce the risk of ulcer. It is best to take prednisone and ibuprofen with a meal to help minimize gastric irritation.
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