when do most take their pills, day, night, 2 pills at a time or 1 pill twice a day, morning and evening? i am also on the Butrans Pain patch for osteoporosis pain. my recent bone density test -4.6 also on Buspirone 2 tablets twice daily and various other drugs for COPD. I was prescribed Cymbalta for osteoporosis pain but have also experience a better attitude, i wake up with goals for the day, b/4 i woke up depressed with no "gumpsion" to do much of anything.