No, it will not cause you to become sick immediately as in nauseated or vomit, but there is the following warning:
naltrexone ↔ ethanol
Applies to: naltrexone, Alcohol (contained in alcoholic beverages) (ethanol)
GENERALLY AVOID: Coadministration of naltrexone with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Naltrexone, especially in larger than recommended doses (more than 50 mg/day), has been associated with hepatocellular injury, hepatitis, and elevations in liver transaminases and bilirubin.
MANAGEMENT: The use of naltrexone in combination with other potentially hepatotoxic agents (e.g., acetaminophen; alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; endothelin receptor antagonists; interferons; nucleoside reverse transcriptase inhibitors; retinoids; thiazolidinediones; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, HMG-CoA reductase inhibitors, and niacin; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice) is generally not recommended unless the potential benefit outweighs the risk. Patients treated with naltrexone should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, light-colored stools, and jaundice. Periodic monitoring of hepatic function is advisable.
So the excessive use of naltrexone with excessive or prolonged use of alcohol may cause liver damage.
Hope this helps,
YES!! I became violently ill after a heavy night of drinking on Naltrexone. Dizzy, massive headache, sweats, extreme nausea and projectile vomiting. Worst sickness I can remember. However, I can't seem to find anything on the web that says it will make you sick.
I am on a combination of 50 mg of Naltrexone and 666 mgs of Campral daily. I drank tonight for the first time after being abstinent for over 2 1/2 months. I decided to indulge and "gather more research" as they say. My findings: drinking is just not as pleasurable as it was before. I had 2 generous glasses of white wine and found that I did not like the taste of it and it made me mildly queasy. I used to be a hardcore binge drinker who thought nothing of consuming 2 large bottles of wine and following it up with a 6 pack. This just is not fun and I feel little incentive to do it again. Leave it to Big Pharma to recalibrate my brain.
I have found that drinking while on Naltrexone had made me extremely ill. Vomiting and headache. Ive only had alcohol twice since taking it, and been very sick both times. I look at it as divine intervention.
- Naltrexone Information for Consumers
- Naltrexone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Naltrexone (detailed)
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