Can I take trazodone and tramadol if I am not taking them together and at least 8hrs apart?

trazodone oral and tramadol oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Monitor CloselyPotential for dangerous interaction... But im no MD lol

I have taken tramadol and another TCA for 10 years. I have never had a problem. Manufacturers have to warn that the potential is there. It does not mean there is going to be one. It wouldn't make a difference when you took them, its having them in your body that could cause a reaction

I would not take these two drugs together. According to drugs.com the interaction between the two is listed as major with serotonin syndrome a possilbe outcome. I had a minor case of serotonin syndrome using tramadol and cymbalta together and ended up in the ER for 7 hours. My MD prescribed both to me and said there would be no problem but he was wrong. Be very careful, please!!!

Neither of these medications are SSRI. Selective Serotonin Reuptake Inhibitors, therefore there is no risk for serotonin syndrome in my opinion.
Please contact your doctor if you are concerned.
Sincerely,
Madhup Joshi, MD
Maui, Hawaii