I am concerned about the possibility of seratonin syndrome, but my doctor prescribed me both medications.
I would not take these two drugs together. According to drugs.com the interaction between the two is listed as major with serotonin syndrome a possilbe outcome. I had a minor case of serotonin syndrome using tramadol and cymbalta together and ended up in the ER for 7 hours. My MD prescribed both to me and said there would be no problem but he was wrong. Be very careful, please!!!
I have taken tramadol and another TCA for 10 years. I have never had a problem. Manufacturers have to warn that the potential is there. It does not mean there is going to be one. It wouldn't make a difference when you took them, its having them in your body that could cause a reaction
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