I take tramadol 50-100mg, 2-3x/day for moderate to severe endometriosis pain (for several years). I'm battling a particularly stubborn bought of insomnia and melatonin/herbal remedies are failing me. I prefer not to take benzodiazepines or Ambien, Soma, or anything of that nature. Have had great success with occasional low dose trazodone for sleep in the past (25-50mg at bedtime). Would not be used daily, just a couple nights per week, the nights before major work events making a decent night's sleep imperative. I have never taken any form of SSRI, but when I plugged in Tramadol and Trazodone, I got a major warning about serotonin syndrome. I'm hoping that refers to taking both drugs concurrently "full time", and that I could safely take a single, low dose of trazodone at bedtime on occasion without risk of serotonin syndrome. Is this accurate?
Tramadol has a norepinephrine as well as a serotonin reuptake inhibitor property. The risk for serotonin syndrome is very low. As far as the trazodone you must measure the benefit versus the side effects. You know your body better than anyone else including your doctor. I believe you should always use the lowest dose possible to gain the best therapeutic response.
Glad you did your research. But it may be best to ask you doctor about taking both meds. Serotonin syndrome is rare, but can happen.
Hope you get some good Zzzzzs soon :)
Serotonin syndrome is rare. I've taken both Tramadol and low dose (25 to 50mg) Trazodone many times. I also take Tramadol with Cymbalta daily. It's fine just be aware of the symptoms of serotonin syndrome in the rare event it would happen.
Hi Mia, I take Prozac 40mg each morning along with Tramadol 100mg 4 times a day prn (as needed) with 200mg Trazadone at bedtime also as needed. I have never had any problems with this combination. As you said it is imperative to get a good nights rest before work to be at your best! I hope this helps! Good luck and God bless!
Yes I t is most likely fine. I take 100 mg tramadol 2x daily and take 200mg of trazodone at night as well as 120mg of cymbalta. No issues for me.
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