I've been on 0.5mg of Rexulti for 3 days for MDD. I was told to take it "before bed". The 1st night I took it at 8pm and was up until 5am, which is very unusual for me. The last 2 nights, I have taken it at 6pm and although it's made me a little drowsy, I've still not been able to fall asleep until between 3:30-4am. I know insomnia is a possible side effect. I'm hoping it will wear off. For those who take it at night/before bed, how long before bed do you take it? If it has caused insomnia, did it eventually wear off?