Can I take amitriptyline and duloxetine?

Taking amitriptyline and duloxetine together requires caution and should be taken under the strict supervision of a doctor. Both of these drugs are antidepressants, but they belong to different classes.
Amitriptyline belongs to the tricyclic antidepressant (TCA) group, while duloxetine belongs to the serotonin and norepinephrine reuptake inhibitor (SNRI) class. Both of these classes of antidepressants can affect neurochemical processes in the brain, and their combination can affect neurotransmitter levels.
Mixing antidepressants can increase side effects and increase the risk of drug-drug interactions. This can include drowsiness, changes in blood pressure, heart problems, and other adverse reactions.

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There is a major interaction between both AD:

Major meaning: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Interactions between your drugs
Major
amitriptyline DULoxetine
Applies to: amitriptyline, duloxetine

Using amitriptyline together with DULoxetine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should seek immediate medical attention if you experience these symptoms while taking the medications. Talk to your doctor if you have any questions or concerns.

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