Meclizine hydrochloride (Antivert, Bonine, Dramamine Less Drowsy Formula) is an antihistamine medication used for motion sickness and vertigo. It is available over-the-counter (for motion sickness only) or with a prescription (for motion sickness or vertigo).
Promethazine hydrochloride (Phenergan) is a prescription medication approved for a variety of widely different uses. It is probably used most often as a nausea medication, although it is frequently used for other purposes as well.
Almost the same uses but Meclizine is also available as an OTC, whereas Promethazine is available on prescription.
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