There is a moderate interaction noted between tizanidine and gabapentin. Please see the link below for interaction in detail.
I would think that sedation would be the issue with taking them together. You would want to space your doses apart rather than taking them at the same time. Both medications can cause considerable sedation so taking the two together would compound that side effect. Try to space them several hours apart.
- Tizanidine Information for Consumers
- Tizanidine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Tizanidine (detailed)
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